Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats.: Part II -: Tissue distribution
Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats.: Part II -: Tissue distribution
复制标题
DOI：
10.1006/phrs.2001.0813
复制
发表时间：
2001-05-01
影响因子：
9.3
通讯作者：
Gasco, MR
中科院分区：
文献类型：
--
作者：
Bargoni, A;Cavalli, R;Gasco, MR
制备妥布霉素固体脂质纳米粒（SLN），并通过十二指肠和静脉（i.v.）给药后30 min、4 h和24 h分别测定SLN在大鼠体内的组织分布，并与妥布霉素溶液静脉给药后的组织分布进行比较。经尿道给予的负载妥布霉素的SLN和静脉给予的妥布霉素溶液之间也存在显著差异。特别是，妥布霉素负载SLN经尿道或静脉给药后肾脏中妥布霉素的量低于静脉给药后的量。与十二指肠给药相比，静脉注射妥布霉素负载的SLN能够在更大程度上通过大鼠的血脑屏障。(C)北京：科学出版社.
Tobramycin-loaded solid lipid nanoparticles (SLN) were prepared and administered by duodenal and intravenous (i.v.) routes to rats and the tissue distributions were determined successively at fixed times (30 min, 4 h and 24 h) and compared to those of the tobramycin solution after i.v. administration.The tissue distribution between tobramycin-loaded SLN administered duodenally and i.v. was different.. A marked difference between tobramycin-loaded SLN administered duodenally and tobramycin solution administered i.v. was also evidenced. In particular, the amounts of tobramycin in the kidneys after tobramycin-loaded SLN administration either duodenally or i.v. were lower than after administration of i.v. solution. Tobramycin-loaded SLN were able to pass across the blood-brain barrier in rats to a greater extent after i.v. injection than after duodenal administration. (C) 2001 Academic Press.