Progenitor cells and glioma formation
Progenitor cells and glioma formation
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DOI：
10.1097/00019052-200112000-00002
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发表时间：
2001-12-01
影响因子：
4.8
通讯作者：
Holland, EC
中科院分区：
文献类型：
--
作者：
Holland, EC
胶质瘤是发生在中枢神经系统内的一组肿瘤，具有类似于星形胶质细胞、少突胶质细胞或其前体细胞的特征。这些肿瘤的胶质细胞特征是否意味着它们起源于它们相似的分化的神经胶质细胞，还是它们的前体，一直存在争议。即使在正常情况下，成人中枢神经系统内的细胞也可以转分化为其他类型的细胞。此外，在胶质瘤中发现的突变进一步破坏了这些细胞的分化状态，使得确定哪种细胞类型导致特定的肿瘤组织学变得困难。动物的谱系追踪研究可以用来将某些特定的细胞特征与由这些细胞产生的胶质瘤的组织学联系起来。这些实验表明，未分化细胞对某些信号异常的致癌效应比分化细胞更敏感，但有了适当的遗传异常，分化的星形胶质细胞可以作为胶质瘤的起源细胞。这些数据表明，促进分化的小分子可能是与其他针对特定分子信号靶点的药物联合治疗胶质瘤的合理组成部分。Curr Opin Neurol 14：683-688。(C)2001年，里平科特·威廉姆斯·威尔金斯。
The gliomas are a collection of tumors that arise within the central nervous system and have characteristics similar to astrocytes, oligodendrocytes, or their precursors. Whether or not the glial characteristics of these tumors mean that they arise from the differentiated glia that they resemble or their precursors has been debated. Even under normal circumstances the cells within the central nervous system of an adult can trans-differentiate to other cell types. In addition, mutations found in gliomas further destabilize the differentiation status of these cells making a determination of what cell type gives rise to a given tumor histology difficult. Lineage tracing studies in animals can be used to correlate some specific cell characteristics with the histology of gliomas that arise from these cells. From these experiments it appears that undifferentiated cells are more sensitive to the oncogenic effects of certain signaling abnormalities than are differentiated cells, but that with the appropriate genetic abnormalities differentiated astrocytes can act as the cell-of-origin for gliomas. These data imply that small molecules that promote differentiation may be a rational component of glioma therapy in combination with other drugs aimed at specific molecular signaling targets. Curr Opin Neurol 14:683-688. (C) 2001 Lippincott Williams Wilkins.