Circumscribed palmar or plantar hypokeratosis: Two cases and a review of published work
Circumscribed palmar or plantar hypokeratosis: Two cases and a review of published work
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局限性手掌或足底角化不足：两个病例和已发表作品的回顾
DOI：
10.1111/j.1346-8138.2011.01259.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
T. Akasaka
中科院分区：
文献类型：
--
作者：
Kiyomi Akasaka;C. Maesawa;Kazuhiro Takahashi;T. Masuda;T. Akasaka
患者，至少自1983年以来，根据Medline的说法。已有报道称，苔藓淀粉样变性与包括特应性皮炎在内的几种皮肤病相关。然而，在接受环孢素治疗的患者中，还没有关于苔藓淀粉样变性的报道。众所周知，PLCNA有时与自身免疫性结缔组织疾病有关，尤其是干燥综合征。据报道，在14例PLCNA患者中，有5例与干燥综合征有关，这表明PLCNA与干燥综合征中的B淋巴细胞障碍有关。PLCNA中的淀粉样蛋白通常由单克隆性Ig轻链组成，这些轻链可能是由渗入皮肤的浆细胞产生的。这位患者没有患有干燥综合征，其免疫力可能受到特应性皮炎和⁄或用于治疗的环孢素A的影响。这是首次报道环孢素A治疗的特应性皮炎患者的PLCNA。虽然这两个因素有可能影响患者的免疫，导致淀粉样结节的形成，但从Ig G kappa轻链沉积淀粉样蛋白的机制仍不清楚。
patients, at least since 1983, according to Medline. Amyloid deposition has been reported in lichen amyloidosis associated with several skin disorders including atopic dermatitis. However, lichen amyloidosis has not been reported in cyclosporine-treated patients. It is well known that PLCNA is sometimes associated with autoimmune connective tissue disorders, especially Sjögren’s syndrome. It has been reported that five out of 14 patients with PLCNA are involved with Sjögren’s syndrome, suggesting that PLCNA is associated with B lymphocyte disorders in Sjögren’s syndrome. The amyloid in PLCNA is usually composed of monoclonal Ig light chains, which are likely produced by plasma cells infiltrated into the skin. The immunity of the present patient, who did not suffer from Sjögren’s syndrome, may have been affected by atopic dermatitis and ⁄ or the cyclosporine used for the treatment. This is the first report of PLCNA in a patient with atopic dermatitis treated with cyclosporine. Although there is a possibility that these two factors affected the immunity of the patient, resulting in the formation of amyloid nodules, the mechanisms for amyloid deposition from IgG kappa light chain is still unknown.