An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized submandibular gland transplantation
An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized submandibular gland transplantation
复制标题
自体缩小颌下腺移植治疗严重干燥性角结膜炎的实验研究。
DOI：
10.1016/j.bjoms.2011.10.004
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发表时间：
2012-09-01
影响因子：
1.8
通讯作者：
Li, Sheng-lin
中科院分区：
文献类型：
--
作者：
Ge, Xi-yuan;Yu, Guang-yan;Li, Sheng-lin
我们评估了减少颌下腺移植治疗严重干燥性角结膜炎的效果。 34 只兔子被分为三组：干眼组（对照组，n = 10）、整个颌下腺移植（a = 12）和缩小颌下腺移植（a = 12）。结果测量包括席默氏试验和玫瑰红试验的结果，以及角膜和移植腺体的组织学检查。与术前引起的干眼相比，整个腺体移植后泪液量显着增加，但缩小的腺体移植后泪液量没有变化。移植组术后均未出现干燥性角结膜炎。移植组织没有组织学异常。结果表明，采用缩小颌下腺进行移植的手术技术是可行的，且缩小腺体的分泌物与正常泪腺相似。总之，减少颌下腺移植治疗干燥性角结膜炎是可行的。 (c) 2011 年由爱思唯尔有限公司代表英国口腔颌面外科医生协会出版。
We have evaluated transplantation of reduced submandibular glands for the treatment of severe keratoconjunctivitis sicca. Thirty-four rabbits were allocated into three groups: dry eye (controls, n = 10), transplantation of whole submandibular glands (a = 12), and transplantation of reduced submandibular glands (a = 12). Outcome measures included the results of Schirmer's test and the Rose Bengal test, and histological examination of the cornea and the transplanted gland. Volume of tears significantly increased after transplantation of the whole gland, but did not change after transplantation of the reduced gland compared with dry eyes induced preoperatively. Neither transplantion group had keratoconjunctivitis sicca postoperatively. There were no histological abnormalities in the transplanted tissues. The results that the surgical technique of using reduced submandibular glands for transplantation was feasible, and that the secretion from the reduced gland was similar to that from a normal lacrimal gland. In conclusion, transplantation of a reduced submandibular glands is feasible in the treatment of keratoconjunctivitis sicca. (c) 2011 Published by Elsevier Ltd on behalf of The British Association of Oral and Maxillofacial Surgeons.