Homogeneous electrocatalytic oxidation of d-penicillamine with ferrocyanide at a carbon paste electrode: application to voltammetric determination
Homogeneous electrocatalytic oxidation of d-penicillamine with ferrocyanide at a carbon paste electrode: application to voltammetric determination
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DOI：
10.1007/s10800-008-9724-y
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发表时间：
2009-06
影响因子：
2.9
通讯作者：
J. Raoof;R. Ojani;Mahsa Majidian;F. Chekin
中科院分区：
文献类型：
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作者：
J. Raoof;R. Ojani;Mahsa Majidian;F. Chekin
采用循环伏安法（CV）和计时电流法研究了在亚铁氰化物作为均匀介质存在下碳膏电极表面上d-青霉胺（d-PA）的电氧化。在CV的最佳pH下，d- pa的氧化电位比没有亚铁氰化物时低380 mV左右。用CV法和差分脉冲伏安法（DPV）分别在d- pa的4.0 × 10−5 ~ 2.0 × 10−3M和8.0 × 10−6 ~ 1.8 × 10−4M范围内得到了催化氧化峰电流。CV法和DPV法检测限（3σ）分别为1.9 × 10 - 5和3.2 × 10 - 6M。该方法也可用于标准加成法测定制剂中d- pa的含量。
The electrooxidation ofd-penicillamine (d-PA) was studied in the presence of ferrocyanide as a homogeneous mediator at the surface of a carbon paste electrode in aqueous media using cyclic voltammetry (CV) and chronoamperometry. Under optimum pH in CV the oxidation ofd-PA occurs at a potential about 380 mV less positive than that in the absence of ferrocyanide. The catalytic oxidation peak current was dependent on thed-PA concentration and a linear calibration curve was obtained in the ranges 4.0 × 10−5–2.0 × 10−3M and 8.0 × 10−6–1.8 × 10−4M ofd-PA with CV and differential pulse voltammetry (DPV) methods, respectively. The detection limits (3σ) were determined as 1.9 × 10−5and 3.2 × 10−6M by CV and DPV methods. This method was also used for the determination ofd-PA in pharmaceutical preparations by the standard addition method.