Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency
Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency
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DOI：
10.1210/jc.2008-0352
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发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Vermiglio, Francesco
中科院分区：
文献类型：
--
作者：
Moleti, Mariacarla;Lo Presti, Vincenzo Pio;Vermiglio, Francesco
内容：妊娠期轻度至中度碘缺乏可导致短暂的母体甲状腺功能减退和后代智力发育受损。这些不利影响可以通过补充碘来预防。然而，在欧洲，不到50%的孕妇接受含碘的补充剂，因此代表膳食碘盐的唯一载体的碘大多数妇女在这个生命阶段。目的/设计：这项纵向研究的目的是调查的影响，长期食用碘盐对母亲的甲状腺功能在怀孕期间。参与者/结果措施：我们前瞻性地评估了100例来自轻度碘缺乏地区的甲状腺过氧化物酶抗体阴性孕妇的甲状腺功能。62名妇女定期使用碘盐至少2年前成为怀孕和38谁开始碘盐消费后成为怀孕被归类为长期（LT）和短期（ST）碘supplemented.Results：长期碘盐消费导致在一个非常低的患病率母亲甲状腺功能衰竭（MTF）LT妇女。相反，短期碘预防似乎不能预防MTF的风险，ST女性的MTF患病率几乎是LT女性的6倍（36.8% vs. 6.4%; chi（2）14.7，P < 0.0005;相对风险5.7，95%置信区间2.03-16.08，P < 0.001）。相对风险降低达82.5%，这一措施表明，在何种程度上，长期碘预防使用碘盐将减少MTF的风险在ST women.Conclusions：延长碘盐显着提高产妇甲状腺经济和降低风险的母亲甲状腺功能不全在妊娠期间，可能是因为一个几乎恢复甲状腺内碘商店。
Context: Mild to moderate iodine deficiency during pregnancy can cause transient maternal hypothyroidism and impaired mental development of the progeny. These unfavorable effects are preventable by iodine supplementation. In Europe, however, less than 50% pregnant women receive iodine-containing supplements, thus representing dietary iodized salt the only carrier of iodine for most women in this life stage.Objective/Design: This longitudinal study is aimed to investigate the effects of long-term iodized salt consumption on maternal thyroid function during gestation.Participants/Outcome Measures: We prospectively evaluated thyroid function in 100 consecutive thyroperoxidase antibody-negative pregnant women from a mildly iodine-deficient area. Sixty-two women who had regularly used iodized salt for at least 2 yr prior to becoming pregnant and 38 who commenced iodized salt consumption upon becoming pregnant were classified as long-term (LT) and short-term (ST) iodine supplemented, respectively.Results: Long-term iodized salt consumption resulted in a very low prevalence of maternal thyroid failure (MTF) in LT women. Conversely, short-term iodine prophylaxis does not seem to protect against the risk of MTF, the prevalence of which was almost 6-fold higher in ST than LT women (36.8% vs. 6.4%; chi(2) 14.7, P < 0.0005; relative risk 5.7, 95% confidence interval 2.03-16.08, P < 0.001). The relative risk reduction amounted to 82.5%, this measure indicating the extent to which long-term iodine prophylaxis using iodized salt would reduce the risk of MTF in ST women.Conclusions: Prolonged iodized salt significantly improves maternal thyroid economy and reduces the risk of maternal thyroid insufficiency during gestation, probably because of a nearly restoring intrathyroidal iodine stores.