SEROLOGICAL SPECIFICITY OF PHENOLIC GLYCOLIPID-I FROM MYCOBACTERIUM-LEPRAE AND USE IN SERODIAGNOSIS OF LEPROSY
SEROLOGICAL SPECIFICITY OF PHENOLIC GLYCOLIPID-I FROM MYCOBACTERIUM-LEPRAE AND USE IN SERODIAGNOSIS OF LEPROSY
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DOI：
10.1128/iai.41.3.1077-1083.1983
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
BRENNAN, PJ
中科院分区：
文献类型：
--
作者：
CHO, SN;YANAGIHARA, DL;BRENNAN, PJ
The serological activities of the specific phenolic glycolipid I from M. leprae, its dissected parts and related glycolipids from other mycobacteria were examined by enzyme-linked immunosorbent assay against hyperimmune anti-M. leprae rabbit antiserum and sera from patients with leprosy and other myocobacterial diseases. High anti-phenolic glycolipid I IgM, and antibodies were found in 23 of 24 (96%) of lepromatous leprosy patients on short term chemotherapy and in 8 of 13 tuberculoid leprosy patients (62%). Sera from patients with tuberculosis or atypical mycobacterial infections were devoid of anti-phenolic glycolipid I activity. The structurally related phenolic glycolipids from M. kansasii and M. bovis and the aglycone segments of the M. leprae product showed no significant activity. Thus, the trisaccharide determinant of phenolic glycolipid I is specific in its structure, serological actiivty and, to a lesser extent, the antibody class it evokes.
