LITHIUM IN HOSPITALIZED AGGRESSIVE-CHILDREN WITH CONDUCT DISORDER - A DOUBLE-BLIND AND PLACEBO-CONTROLLED STUDY
LITHIUM IN HOSPITALIZED AGGRESSIVE-CHILDREN WITH CONDUCT DISORDER - A DOUBLE-BLIND AND PLACEBO-CONTROLLED STUDY
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DOI：
10.1097/00004583-199504000-00011
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发表时间：
1995-04-01
影响因子：
13.3
通讯作者：
OVERALL, JE
中科院分区：
文献类型：
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作者：
CAMPBELL, M;ADAMS, PB;OVERALL, JE
目的：批判性地评估锂的有效性和安全性，并在更大的具有行为障碍的攻击性儿童样本中重复先前的研究结果，并评估情绪状态谱（POMS）在这一人群中的效用。方法：采用双盲、安慰剂对照的临床试验，以难治性、严重攻击性、爆发性和诊断为品行障碍的住院儿童为研究对象。在2周的安慰剂基线期后，儿童被随机分配到锂或安慰剂治疗6周，然后是2周的安慰剂。主要观察指标为全球临床判断（共识）量表、儿童精神病学评定量表、Conners教师问卷、家长教师问卷和POMS。结果：50名儿童（平均年龄9.4岁）完成了本研究。锂的平均最佳日剂量为1248 mg，平均血清水平为1.12 mEq/L。锂优于安慰剂，尽管在某些方面的效果比之前的研究要温和。结论：锂似乎是一种有效的治疗一些严重的攻击性儿童行为障碍。尽管POMS似乎是可靠的，但它没有检测到对锂的任何反应。
Objective: To assess critically the efficacy and safety of lithium and replicate earlier findings in a larger sample of aggressive children with conduct disorder and to assess the utility of the Profile of Mood States (POMS) in this population. Method: Children hospitalized for treatment-refractory severe aggressiveness and explosiveness and with diagnosed conduct disorder were subjects in this double-blind, placebo-controlled clinical trial. After a 2-week placebo baseline period, children were randomly assigned to lithium or placebo treatment for 6 weeks followed by 2 weeks of placebo. The main outcome measures were the Global Clinical Judgments (Consensus) Scale, Children's Psychiatric Rating Scale, Conners Teacher Questionnaire, Parent-Teacher Questionnaire, and the POMS. Results: Fifty children (mean age 9.4 years) completed this study. The mean optimal daily dose of lithium was 1,248 mg and the mean serum level was 1.12 mEq/L. Lithium was superior to placebo, although the effects on some measures were more modest than in a previous study. Conclusions: Lithium appears to be an effective treatment for some severely aggressive children with conduct disorder. Although the POMS appeared to be reliable, it did not detect any response to lithium.