Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis
Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis
复制标题
DOI：
10.1021/np050483q
复制
发表时间：
2006-08-25
影响因子：
5.1
通讯作者：
Sheu, Jyh-Horng
中科院分区：
文献类型：
--
作者：
Su, Jui-Hsin;Ahmed, Atallah F.;Sheu, Jyh-Horng
从台湾软珊瑚Sinularia manaarensis的乙酸乙酯提取物中分离出9个膜型二萜，manaarenides A-I(1-9)，以及2个已知的cembranolides 10和11。在这些代谢产物中，二萜（1、2、5和6）首次被发现为具有三角内酯环的氢过氧烃内酯。13-外显子代谢物7和8对Hepa59T/ VGH、KB、Hela和Med癌细胞具有中等的细胞毒活性。并讨论了这些新代谢物与10和11的生物合成关系。
Nine cembrane-type diterpenoids, manaarenolides A-I(1-9), along with two known cembranolides, 10 and 11, have been isolated from the ethyl acetate extract of the Taiwanese soft coral Sinularia manaarensis. Among these metabolites, diterpenes ( 1, 2, 5, and 6) were discovered for the first time as the hydroperoxycembranolides possessing a delta-lactone ring. The 13-epimeric metabolites 7 and 8 have been shown to exhibit moderate cytotoxic activity against Hepa59T/ VGH, KB, Hela, and Med cancer cell lines. The biosynthetic relationship between these new metabolites and 10 and 11 is also discussed.