Mammalian epididymal proteome
Mammalian epididymal proteome
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DOI：
10.1016/j.mce.2009.03.007
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发表时间：
2009-07-10
影响因子：
4.1
通讯作者：
Dacheux, Francoise
中科院分区：
文献类型：
--
作者：
Dacheux, Jean-Louis;Belleannee, Clemence;Dacheux, Francoise
在所有的哺乳动物物种中，雄性生殖细胞的最终分化发生在附睾管中，在那里精子发展出运动和使卵子受精的能力。了解这些生物学过程是理解和控制男性生育能力的关键。几种哺乳动物之间的比较研究可能是一种信息丰富的方法，以找到共同的精子修饰，这是不是物种特异性。新的全球生物学方法，如转录组和蛋白质组提供了大量的信息，可用于这种比较方法。本文总结了我们对包括人类在内的几种哺乳动物附睾的蛋白质组学研究。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
In all mammalian species, the final differentiation of the male germ cell occurs in the epididymal duct where the spermatozoa develop the ability to be motile and fertilize an ovum. Understanding of these biological processes is the key to understanding and controlling male fertility. Comparative studies between several mammals could be an informative approach to finding common sperm modifications which are not species-specific. The new global biological approaches such as transcriptomes and proteomes provide considerable information which can be used for such comparative approaches. This report summarizes our proteomic studies of the epididymis of several mammals, including humans. (C) 2009 Elsevier Ireland Ltd. All rights reserved.