Functional Connectivity between Anatomically Unconnected Areas Is Shaped by Collective Network-Level Effects in the Macaque Cortex
Functional Connectivity between Anatomically Unconnected Areas Is Shaped by Collective Network-Level Effects in the Macaque Cortex
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DOI：
10.1093/cercor/bhr234
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发表时间：
2012-07-01
期刊：
影响因子：
3.7
通讯作者：
Miyashita, Yasushi
中科院分区：
文献类型：
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作者：
Adachi, Yusuke;Osada, Takahiro;Miyashita, Yasushi
一致的自发血氧水平依赖(BOLD)波动作为灵长类新皮质功能连通性(FC)的一种测量手段已被广泛研究。BOLD-FC通常被认为受到潜在的解剖连接(AC)的限制；然而，没有直接AC的大脑皮层区域对也可能具有很强的BOLD-FC。关于在没有直接交流的情况下产生FC的机制，有两种可能性：1)FC是由短连接模式的信号流决定的，例如由第三个区域介导的串联中继器和公共传入；2)FC是由大脑皮层网络属性支配的集体效应决定的。在这项研究中，我们对麻醉猕猴进行了功能磁共振成像，发现未连接区域之间的BOLD-FC依赖于通过第三个区域的串联中继，而不是共同的传入和出乎意料的共同传出，这与第一种可能性不匹配。通过利用区域间BOLD-FC网络的计算模型，我们表明经验检测到的AC-FC关系反映了皮质解剖网络中的网络构建块(Motif)的配置，这支持第二种可能性。我们的研究结果表明，FC不是仅仅由区域间短连接模式决定的，而是受到网络水平的皮质结构的很大影响。
Coherent spontaneous blood oxygen level-dependent (BOLD) fluctuations have been intensely investigated as a measure of functional connectivity (FC) in the primate neocortex. BOLD-FC is commonly assumed to be constrained by the underlying anatomical connectivity (AC); however, cortical area pairs with no direct AC can also have strong BOLD-FC. On the mechanism generating FC in the absence of direct AC, there are 2 possibilities: 1) FC is determined by signal flows via short connection patterns, such as serial relays and common afferents mediated by a third area; 2) FC is shaped by collective effects governed by network properties of the cortex. In this study, we conducted functional magnetic resonance imaging in anesthetized macaque monkeys and found that BOLD-FC between unconnected areas depends less on serial relays through a third area than on common afferents and, unexpectedly, common efferents, which does not match the first possibility. By utilizing a computational model for interareal BOLD-FC network, we show that the empirically detected AC-FC relationships reflect the configuration of network building blocks (motifs) in the cortical anatomical network, which supports the second possibility. Our findings indicate that FC is not determined solely by interareal short connection patterns but instead is substantially influenced by the network-level cortical architecture.