A unitary model of schizophrenia -: Bleuler's "fragmented phrene" as schizencephaly
A unitary model of schizophrenia -: Bleuler's "fragmented phrene" as schizencephaly
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DOI：
10.1001/archpsyc.56.9.781
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发表时间：
1999-09-01
影响因子：
--
通讯作者：
Andreasen, NC
中科院分区：
文献类型：
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作者：
Andreasen, NC
在精神分裂症的症状和体征的多样性背后找到一个统一的概念是当代研究的一个核心挑战。描述了一种新布勒单一模型，该模型将疾病定义为神经发育衍生的“错误连接综合征”，涉及通过丘脑介导的皮质区域和小脑之间的连接（皮质-小脑-丘脑-皮质回路[CCTCC]）。这种通常用于协调运动和心理活动的回路的异常，会导致心理活动的许多方面的错误连接，或“认知失调”。正如布莱德利最初提出的，“思维障碍”是精神分裂症的主要特征，而不是更明显的症状和体征，如妄想和幻觉。认知辨距障碍，或在CCTCC的障碍，可以提供一个启发式的理论框架的策略，探索病因，病理生理，干预，或预防。
Finding a unifying concept behind the diversity of signs and symptoms in schizophrenia is a central challenge to contemporary research. A neo-Bleulerian unitary model is described, which defines the illness as a neurodevelopmentally derived "misconnection syndrome," involving connections between cortical regions and the cerebellum mediated through the thalamus (the cortico-cerebellar-thalamic-cortical circuit [CCTCC]). An abnormality in this circuitry, normally used to coordinate both motor and mental activity, leads to misconnections in many aspects of mental activity, or "cognitive dysmetria." As Bleuler originally proposed, "thought disorder" is the primary defining feature of schizophrenia, rather than the more obvious signs and symptoms such as delusions and hallucinations. Cognitive dysmetria, or a disorder in the CCTCC, may provide a heuristic theoretical framework for strategies to explore etiology, pathophysiology, intervention, or prevention.