ANDROGEN INHIBITS THE INCREASES IN HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE (CRH) AND CRH-IMMUNOREACTIVITY FOLLOWING GONADECTOMY
ANDROGEN INHIBITS THE INCREASES IN HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE (CRH) AND CRH-IMMUNOREACTIVITY FOLLOWING GONADECTOMY
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DOI：
10.1159/000126663
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发表时间：
1994-03-01
影响因子：
4.1
通讯作者：
HANDA, RJ
中科院分区：
文献类型：
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作者：
BINGAMAN, EW;MAGNUSON, DJ;HANDA, RJ
为了描述雄激素对下丘脑-垂体-肾上腺（HPA）轴的影响，我们研究了性腺切除术和激素替代后促肾上腺皮质激素释放激素（CRH）的调节。将3月龄雄性Fischer 344（F344）大鼠进行性腺切除（GDX）或假GDX。对照动物保持完整。手术后1、4、7、10或21天处死动物。GDX组与对照组相比，
To characterize the effect of androgens on the hypothalamo-pituitary-adrenal (HPA) axis we examined the regulation of corticotropin-releasing hormone (CRH) following gonadectomy and hormone replacement. Three-month-old male Fischer 344 (F344) rats were gonadectomized (GDX) or sham GDX. Control animals remained intact. Animals were sacrificed 1, 4, 7, 10, or 21 days following surgery. GDX rats had significantly elevated (p