Relative influence of obesity and diabetes on plasma alpha-cell glucagon.
Relative influence of obesity and diabetes on plasma alpha-cell glucagon.
复制标题
肥胖和糖尿病对血浆α细胞胰高血糖素的相对影响。
DOI：
10.1210/jcem-38-2-238
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
Ronald K. Kalkhoff
中科院分区：
文献类型：
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作者：
Ved V. Gossain;Maria L. Matute;Ronald K. Kalkhoff
摘要关于肥胖和糖尿病对胰腺α细胞功能的影响，已有一些明确的报道。由于这个原因，血浆胰高血糖素测量在30分钟静脉注射精氨酸（1.0 g/min）和葡萄糖（1.5 g/min）和400 g瘦牛肉餐后，肥胖和瘦的非糖尿病和糖尿病妇女。在非糖尿病的瘦型和肥胖型组中，胰高血糖素的基础水平相当，在葡萄糖输注过程中显著抑制，在口服蛋白质餐后升高至相似的峰值。糖尿病女性的空腹胰高血糖素浓度比对照组高20%，尽管空腹高血糖，但在葡萄糖给药后没有抑制。胰高血糖素对口服蛋白质的反应与非糖尿病受试者相似，尽管在整个过程中浓度较高，并伴有血糖曲线异常升高。巧合的是，精氨酸输注引起非糖尿病肥胖妇女以及两组肥胖妇女胰高血糖素的增加。
ABSTRACT Conflicting reports exist regarding the effects of obesity and diabetes on pancreatic alpha-cell function. For this reason plasma glucagon was measured in obese and lean nondiabetic and diabetic women during 30-min intravenous infusions of arginine (1.0 g/min) and glucose (1.5 g/min) and after a 400 g lean beef meal. Basal levels of glucagon were comparable in lean and obese nondiabetic groups, suppressed significantly during glucose infusions and rose to similar peak values after oral protein meals. Fasting glucagon concentrations in diabetic women were 20% higher than control levels despite fasting hyperglycemia and did not suppress after glucose administration. Glucagon responses to oral protein resembled those of nondiabetic subjects, although concentrations were higher throughout the procedure in association with abnormally elevated plasma glucose curves. Paradoxically, arginine infusions elicited greatly augmented increments of glucagon in nondiabetic obese women as well as in both groups o...