Evolutionary patterns of the mitochondrial genome in Metazoa: exploring the role of mutation and selection in mitochondrial protein coding genes.
Evolutionary patterns of the mitochondrial genome in Metazoa: exploring the role of mutation and selection in mitochondrial protein coding genes.
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DOI：
10.1093/gbe/evr040
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Saccone C
中科院分区：
文献类型：
--
作者：
Castellana S;Vicario S;Saccone C
线粒体基因组是真核生物生命域的基本组成部分，编码呼吸链的几个重要亚基，呼吸链是细胞中主要的能量生产系统。线粒体DNA （mtDNA）复制、表达和进化的过程多年来一直在探索，尽管各个方面仍存在争议。在这篇综述中，我们介绍了现代研究中进化力量在影响后生动物线粒体基因组中的作用的几个关键点。特别是，我们收集了它们进化的主要数据，描述了突变压力、净化和适应选择的贡献，以及它们之间的关系。我们还提供了与细胞核中检测到的模式相比，线粒体同义变异与非同义变异相关的进化命运的数据。升高的突变压力是线粒体同义变异进化的特征，而清除选择，生理上由于细胞闭锁和细胞内mtDNA选择等现象，保证了编码序列的功能。这使得线粒体适应性突变在种群中出现并固定，促进了线粒体核的共同进化。
The mitochondrial genome is a fundamental component of the eukaryotic domain of life, encoding for several important subunits of the respiratory chain, the main energy production system in cells. The processes by means of which mitochondrial DNA (mtDNA) replicates, expresses itself and evolves have been explored over the years, although various aspects are still debated. In this review, we present several key points in modern research on the role of evolutionary forces in affecting mitochondrial genomes in Metazoa. In particular, we assemble the main data on their evolution, describing the contributions of mutational pressure, purifying, and adaptive selection, and how they are related. We also provide data on the evolutionary fate of the mitochondrial synonymous variation, related to the nonsynonymous variation, in comparison with the pattern detected in the nucleus. Elevated mutational pressure characterizes the evolution of the mitochondrial synonymous variation, whereas purging selection, physiologically due to phenomena such as cell atresia and intracellular mtDNA selection, guarantees coding sequence functionality. This enables mitochondrial adaptive mutations to emerge and fix in the population, promoting mitonuclear coevolution.
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DOI：
10.1098/rspb.2009.0752
发表时间：
2009-10-07
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Balloux F;Handley LJ;Jombart T;Liu H;Manica A
通讯作者：
Manica A
Biopython：用于计算分子生物学和生物信息学的免费 Python 工具。
DOI：
10.1093/bioinformatics/btp163
发表时间：
2009-06-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Cock PJ;Antao T;Chang JT;Chapman BA;Cox CJ;Dalke A;Friedberg I;Hamelryck T;Kauff F;Wilczynski B;de Hoon MJ
通讯作者：
de Hoon MJ
影响因子：
4.4
作者：
Azevedo L;Carneiro J;van Asch B;Moleirinho A;Pereira F;Amorim A
通讯作者：
Amorim A
影响因子：
4.8
作者：
Barrientos, A;Kenyon, L;Moraes, CT
通讯作者：
Moraes, CT
影响因子：
64.8
作者：
EPHRUSSI, B;SLONIMSKI, PP
通讯作者：
SLONIMSKI, PP