Spatial Learning in Male and Female Long-Evans Rats
Spatial Learning in Male and Female Long-Evans Rats
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DOI：
10.1037/bne0000437
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发表时间：
2021-02-01
影响因子：
1.9
通讯作者：
Gallagher, Michela
中科院分区：
文献类型：
--
作者：
Bucci, David J.;Chiba, Andrea A.;Gallagher, Michela
6月龄雄性和雌性Long-Evans大鼠在Morris水迷宫中进行测试。在一个地方训练程序中，老鼠学习伪装平台的位置，然后是线索训练，在这个过程中，老鼠逃到一个可见的平台上。就地学习能力没有性别差异。在探测试验中，当平台不可用时，男性和女性群体的搜索精度也是相同的。这些结果与之前对年龄较小的啮齿动物的研究形成了鲜明对比，后者报告称，雄性在空间学习方面具有优势。这表明，评估大鼠的年龄可能是一个重要因素，可能反映了雄性和雌性大鼠海马体相对较长成熟的不同过程。这项调查的结果也参考了人类空间能力的性别差异的研究进行了讨论。
Male and female Long-Evans rats were tested in the Morris water maze at 6 months of age. A place training procedure, in which rats learned the position of a camouflaged platform, was followed by cue training, in which rats escaped to a visible platform. No sex difference was found in place learning ability. Search accuracy on probe trials, when the platform was unavailable, was also equivalent for the male and female groups. These results contrast with previous studies of rodents at younger ages, which have reported a male advantage in spatial learning. It is suggested that the age at which rats are assessed may be an important factor, possibly reflecting a different course in the relatively protracted maturation of the hippocampus in male and female rats. The results of this investigation are also discussed with reference to studies of sex differences for spatial abilities in humans.