Spatial learning/memory and social and nonsocial behaviors in the spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rat strains
Spatial learning/memory and social and nonsocial behaviors in the spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rat strains
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DOI：
10.1016/j.pbb.2003.12.014
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发表时间：
2004-03-01
影响因子：
3.6
通讯作者：
Cada, AM
中科院分区：
文献类型：
--
作者：
Ferguson, SA;Cada, AM
自发性高血压大鼠(SHR)经常被描述为行为反应性低于其正常血压品系Wistar-京都(WKY)，尽管研究结果有些不一致。在某种程度上，这可能是由于缺乏对“反应性”的明确描述。尽管如此，跨研究对SHR和WXY进行相同的行为测试的结果有时会相互矛盾。此外，与其他啮齿动物品系的比较很少，这些可能会为概述反应性的含义提供指导。本研究测量了雄性和雌性SHR、WKY和SD大鼠的社会和非社会行为以及空间学习和记忆。成年时的收缩压测量证实SHR存在高血压。幼年玩耍行为表明，SHR比WKY或SD对玩耍伙伴的压力更敏感，与不同品系伙伴的游戏比与相同品系伙伴的游戏更少。然而，成虫的显性行为(在水竞争测试中限制进入)表明没有品系差异。与WXY和SD相比，SHR似乎表现出减弱的声惊吓，在较高的预脉冲分贝强度下，它们的预脉冲抑制明显较小；然而，这种减少的脉冲前抑制并不是测试过程中惊吓减少的结果。在SD品系中，与焦虑相关的行为在高架加迷宫中最为突出，这可能是由于旋转木棒表现的运动协调性较差所致。SHR和WKY品系之间的高架迷宫行为和运动协调能力没有差异。SHR在NCTR复合迷宫和Morris水迷宫中的表现明显优于对照组。这些结果不支持SHR品系行为反应性降低的假设。相反，它们表明社会和非社会环境与老鼠品系的行为能力和要求之间存在复杂的相互作用。(C)2004 Elsevier Inc.保留所有权利。
The Spontaneously Hypertensive rat (SHR) is often described as less behaviorally reactive than its normotensive strain, the Wistar-Kyoto (WKY), although results are somewhat inconsistent across studies. In part, this may be due to the lack of a definitive characterization of "reactivity." Still, results from identical behavioral tests of SHR and WXY across studies are sometimes conflicting. Further, few comparisons with other rodent strains are available and these might provide guidance in outlining the meaning of reactivity. Here, social and nonsocial behaviors and spatial learning and memory were measured in male and female SHR, WKY, and Sprague-Dawley (SD) rats. Systolic blood pressure measurements at adulthood confirmed hypertension in the SHR. Juvenile play behavior indicated that SHRs were more sensitive to the strain of their play partner than were the WKY or SD, playing less with different strain partners than with same strain partners. However, adult dominance behavior (restricted access in a water competition test) indicated no strain differences. The SHR appeared to exhibit attenuated acoustic startle relative to the WXY and SD and their prepulse inhibition was substantially less at higher prepulse decibel intensities; however, this decreased prepulse inhibition was not the result of decreased startle during the test. Anxiety-related behavior in the elevated plus maze was most prominent in the SD strain, possibly as a result of poorer motor coordination as measured by rotarod performance. Elevated plus maze behavior as well as motor coordination did not differ between the SHR and WKY strains. Performance in the NCTR complex maze and the Morris water maze was significantly better in the SHR. These results do not support hypotheses of decreased behavioral reactivity in the SHR strain. Rather, they suggest complex interactions between social and nonsocial environments and the behavioral capabilities and requirements of the rat strain. (C) 2004 Elsevier Inc. All rights reserved.