DNA block copolymer micelles - A combinatorial tool for cancer Nanotechnology
DNA block copolymer micelles - A combinatorial tool for cancer Nanotechnology
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DOI：
10.1002/adma.200700866
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发表时间：
2008-03-05
影响因子：
29.4
通讯作者：
Herrmann, Andreas
中科院分区：
文献类型：
--
作者：
Alemdaroglu, Fikri E.;Alemdaroglu, N. Ceren;Herrmann, Andreas
介绍了一种由两亲性DNA嵌段共聚物组成的新型胶束平台，用于化疗药物输送，允许对药物载体系统进行组合测试。寡聚脱氧核苷酸修饰的靶向单元通过杂交被“点击”到胶束电晕中，从而允许完美地控制纳米粒子系统的表面功能。当靶向单元和化疗药物在DNA嵌段共聚聚合物聚集体中共同作用时，癌细胞可以有效地被杀死。
A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxy-nucleotide modified targeting units are "clicked" into the micelle corona by hybridization, allowing perfect control of surface functionalities of the nano-particle system. Cancer cells are efficiently killed when targeting units and chemotherapeutic act together within the DNA block copolymer aggregates.