Identification of a regulatory allele of teashirt (tsh) in Drosophila melanogaster that affects wing hinge development. An adult-specific tsh enhancer in Drosophila
Identification of a regulatory allele of teashirt (tsh) in Drosophila melanogaster that affects wing hinge development. An adult-specific tsh enhancer in Drosophila
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DOI：
10.1016/s0925-4773(01)00397-5
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发表时间：
2001-07
影响因子：
2.6
通讯作者：
K. Soanes;Julie O. MacKay;N. Coré;T. Heslip;S. Kerridge;J. Bell
中科院分区：
文献类型：
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作者：
K. Soanes;Julie O. MacKay;N. Coré;T. Heslip;S. Kerridge;J. Bell
本文定义的顺式作用调控元件需要在发育中的成人产生近端翅膀和胸部组织的区域驱动t恤衫（tsh）表达。这种表达的缺失导致了翅膀近端结构和胸部角质层的融合。这是首次描述了具有可见表型的成人特异性tsh调控等位基因，并扩大了我们对成人发育过程中tsh表达及其功能的理解。
A cis-acting regulatory element defined herein is required to drive teashirt (tsh) expression in the regions of the developing adult that give rise to proximal wing and haltere tissues. Loss of this expression results in the fusion of the proximal structures of the wing and halteres to the thoracic cuticle. This represents the first description of a viable adult-specific regulatory allele of tsh with a visible phenotype, and it enlarges our understanding of the expression of tsh and its function during the development of the adult.