Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study
Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study
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DOI：
10.1002/cncr.29907
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发表时间：
2016-04-15
期刊：
影响因子：
6.2
通讯作者：
Tabori, Uri
中科院分区：
文献类型：
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作者：
Krishnatry, Rahul;Zhukova, Nataliya;Tabori, Uri
背景影响儿童低级别胶质瘤(PLGG)患者预后的主要因素目前尚不清楚。方法：本研究收集了1985年至2012年在加拿大安大略省确诊的所有PLGG患者(n=1202)的基于人群的随访信息，并确定了影响生存的因素。预先放射治疗对安大略省患者和来自监测、流行病学和结局数据库的独立参考队列的总生存率(OS)的影响被确定。结果平均随访12.73年(范围为0.02-33年)，只有93例死亡(7.7%)，20年OS率为90.1%-1.1%。患有1型神经纤维瘤病的儿童成年期存活良好，无肿瘤相关死亡。不良危险因素包括多形性黄色星形细胞瘤(P
BACKGROUNDThe determinants of outcomes for adult survivors of pediatric low-grade glioma (PLGG) are largely unknown.METHODSThis study collected population-based follow-up information for all PLGG patients diagnosed in Ontario, Canada from 1985 to 2012 (n=1202) and determined factors affecting survival. The impact of upfront radiation treatment on overall survival (OS) was determined for a cohort of Ontario patients and an independent reference cohort from the Surveillance, Epidemiology, and End Results database.RESULTSAt a median follow-up of 12.73 years (range, 0.02-33 years), only 93 deaths (7.7%) were recorded, and the 20-year OS rate was 90.1%1.1%. Children with neurofibromatosis type 1 had excellent survival and no tumor-related deaths during adulthood. Adverse risk factors included pleomorphic xanthoastrocytoma (P