Sex difference in cardiometabolic risk profile and adiponectin expression in subjects with visceral fat obesity
Sex difference in cardiometabolic risk profile and adiponectin expression in subjects with visceral fat obesity
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DOI：
10.1016/j.trsl.2009.08.003
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发表时间：
2010-02-01
影响因子：
7.8
通讯作者：
Zhu, Zhiming
中科院分区：
文献类型：
--
作者：
He, Hongbo;Ni, Yinxing;Zhu, Zhiming
本研究旨在探讨腰围正常的内脏脂肪性肥胖（VFO）受试者的心血管代谢风险特征的性别差异。在437名正常WC受试者（197名女性受试者和240名男性受试者）中评估了VFO（定义为计算机断层扫描（CT）显示的内脏脂肪组织（VAT）面积超过100 cm（2））和心脏代谢风险特征。测定一个亚组受试者腹部脂肪组织中脂联素及其受体的表达。女性腹部皮下脂肪（SAT）面积大于男性（158 ± 56 vs 116 ± 38 cm 2，P < 0.01），VAT面积小于男性（67.44vs78 ± 33 cm 2，P <0.01），VFO患病率低于男性（12.2vs24.2%，P < 0.001）。这一发现伴随着女性受试者腹部脂肪组织中脂联素及其受体的表达上调。在无VFO的情况下，男性受试者和女性受试者的风险特征无显著差异。尽管在VFO存在的情况下，两种性别的风险因素均增加并加剧，但女性VFO受试者的心脏代谢风险高于男性受试者。回归分析表明女性受试者的VAT/SAT比值，而男性受试者的VAT和年龄与多个心脏代谢危险因素的聚集独立相关。因此，在正常WC的受试者中，女性VFO的患病率较低，脂联素及其受体的表达高于男性。虽然VFO与男女的风险增加有关，但女性VFO受试者的风险特征更为明显。（翻译研究2010;155：71-77）
This study investigates the sex difference of cardiometabolic risk profiles in subjects with visceral fat obesity (VFO) but normal waist circumference (WC). VFO, which is defined as visceral adipose tissue (VAT) area more than 100cm(2) by computed tomography (CT), and cardiometabolic risk profiles were assessed in 437 subjects with normal WC (197 female subjects and 240 male subjects). The expression of adiponectin and its receptor in abdominal adipose tissue was measured in a subgroup of the subjects. Compared with the male subjects, female subjects had a larger abdominal subcutaneous adipose tissue (SAT) area (158 +/- 56 vs 116 +/- 38cm(2), P < 0.01), smaller VAT area (67 44 vs 78 +/- 33cm(2); P < 0.01), and lower prevalence of VFO (12.2 vs 24.2%, P < 0.001). This finding was accompanied by upregulated expressions of adiponectin and its receptor in abdominal adipose tissue in female subjects. Without VFO, the risk profiles were not significantly different between male subjects and female subjects. Although risk factors were increased and intensified in both sexes in the presence of VFO, female subjects with VFO were associated with greater cardiometabolic risks than male subjects. A regression analysis indicates the ratio of VAT/SAT for female subjects, whereas VAT and age for male subjects were independently associated with clustering of multiple cardiometabolic risk factors. In conclusion, in subjects with normal WC, the prevalence of VFO is lower and the expression of adiponectin and its receptor is higher in female subjects compared with male subjects. Although VFO was associated with increased risk in both sexes, the risk profile in female subjects with VFO was more pronounced. (Translational Research 2010;155:71-77)