Risk of hypertension into adulthood in persons born prematurely: a national cohort study.
Risk of hypertension into adulthood in persons born prematurely: a national cohort study.
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DOI：
10.1093/eurheartj/ehz904
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发表时间：
2020-04-21
影响因子：
39.3
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
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作者：
Crump, Casey;Sundquist, Jan;Sundquist, Kristina
目标：早产与生命早期血压升高有关;然而，从儿童到成年的高血压风险仍不清楚。我们进行了一项大规模的人群研究，以检查出生时的胎龄与从儿童到成年的高血压风险的关系。在1973-2014年期间，对瑞典所有4193069例单胎活产婴儿进行了一项全国性队列研究，从全国范围内的住院和门诊患者中发现高血压患者，（专科和初级保健）诊断从任何医疗保健接触到2015年（最大年龄43岁;中位数22.5）。考克斯回归分析用于检查出生时胎龄与高血压风险的关系，同时调整其他围产期和母亲因素，同胞分析评估未测量的共同家族（遗传和/或环境）因素的潜在影响。在8680万人年的随访中，62424人（1.5%）被确定患有高血压（诊断时的中位年龄为29.8岁）。年龄18- 29岁新发高血压与早产相关的校正风险比（
AIMS: Preterm birth has been associated with elevated blood pressure early in life; however, hypertension risks from childhood into adulthood remain unclear. We conducted a large population-based study to examine gestational age at birth in relation to hypertension risks from childhood into adulthood.METHODS AND RESULTS: A national cohort study was conducted of all 4193069 singleton live births in Sweden during 1973-2014, who were followed up for hypertension identified from nationwide inpatient and outpatient (specialty and primary care) diagnoses from any health care encounters through 2015 (maximum age 43years; median 22.5). Cox regression was used to examine gestational age at birth in relation to hypertension risk while adjusting for other perinatal and maternal factors, and co-sibling analyses assessed the potential influence of unmeasured shared familial (genetic and/or environmental) factors. In 86.8 million person-years of follow-up, 62424 (1.5%) persons were identified with hypertension (median age 29.8years at diagnosis). Adjusted hazard ratios for new-onset hypertension at ages 18-29years associated with preterm (