The time-course of electrocardiographic interbeat interval dynamics in alcoholic subjects after short-term abstinence
The time-course of electrocardiographic interbeat interval dynamics in alcoholic subjects after short-term abstinence
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DOI：
10.1016/s0014-2999(01)01247-x
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发表时间：
2001-09-21
影响因子：
5
通讯作者：
DePetrillo, PB
中科院分区：
文献类型：
--
作者：
Karimullah, K;George, DT;DePetrillo, PB
酒精依赖与心率变异性的降低有关。然而，停止饮酒后心率变异性恢复的时间过程尚不清楚。我们使用从解毒酒精受试者群体连续获得的心电图（ECG）数据来确定心电图搏动间隔时间序列的赫斯特指数。当H小于或等于0.5时，较高的Hurst指数值与心率变异性降低有关。我们测试了一系列与Hurst指数(H)相关的响应面模型，从而获得了以下自变量：时间间隔T（自上次使用酒精以来的天数），a（入院时的年龄）和性别。最佳拟合模型为：H(T) = (KA + HmT + HfT)/(1 + T), F = 5.2， P(F)≤0.01。模型参数：K = 0.008 +/- 0.002（平均+/- SEM）；男女的渐近h值：H-m = 0.24 +/- 0.02, H-f = 0.16 +/- 0.03, P≤0.05时差异有统计学意义。在这个酗酒人群样本中，年龄是初始h值的最强预测因子。(C) 2001年Elsevier Science B.V.出版
Alcohol dependence has been correlated with decreases in heart rate variability. However, the time course of recovery of heart rate variability after cessation of alcohol consumption is unknown. We used electrocardiogram (ECG) data serially obtained from a population of detoxifying alcoholic subjects to determine the Hurst exponent of the ECG interbeat interval time series. Higher values of the Hurst exponent are associated with decreased heart rate variability when H less than or equal to 0.5. We tested a series of response-surface models relating the Hurst exponent (H) thus obtained to the following independent variables: the time interval T (days since last use of alcohol), A (age in years at time of admission), and gender. The best-fit model was: H(T) = (KA + HmT + HfT)/(1 + T), F = 5.2, P(F) less than or equal to 0.01. Model parameters were: K = 0.008 +/- 0.002 (mean +/- SEM); asymptotic H-values for males and females: H-m = 0.24 +/- 0.02 and H-f = 0.16 +/- 0.03, respectively, significantly different at P less than or equal to 0.05. Age was the strongest predictor of initial H-values in this alcoholic population sample. (C) 2001 Published by Elsevier Science B.V.