Task-Specific Somatosensory Feedback via Cortical Stimulation in Humans.
Task-Specific Somatosensory Feedback via Cortical Stimulation in Humans.
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DOI：
10.1109/toh.2016.2591952
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发表时间：
2016-10
影响因子：
2.9
通讯作者：
Olson JD
中科院分区：
文献类型：
--
作者：
Cronin JA;Wu J;Collins KL;Sarma D;Rao RP;Ojemann JG;Olson JD
通过皮层电图（ECoG）电极的皮层刺激是一种潜在的方法，在未来的假肢和康复应用提供感觉反馈。在这里，我们评估人类受试者的能力，不断调整他们的运动行为的基础上反馈的直接表面刺激的躯体感觉皮层。受试者戴着一个数据手套，测量他们的手孔位置，并根据他们当前的手位置与目标孔位置相比，在手感觉皮层上接受三种刺激之一。使用皮层刺激反馈，受试者调整他们的手孔向目标孔区域移动。一名受试者能够达到准确度，R2值远高于机会（最佳性能：R2 = 0.93;准确度= 0.76/1）。在接球试验中（相同的刺激与位置无关），表现下降到低于机会水平，这表明受试者一直在使用各种感觉反馈来调节他们的运动行为。据我们所知，这项研究代表了使用人类感觉皮层的直接皮层表面刺激来执行运动任务的首批演示之一，并且是开发闭环人类感觉运动脑机接口的第一步。
Cortical stimulation through electrocorticographic (ECoG) electrodes is a potential method for providing sensory feedback in future prosthetic and rehabilitative applications. Here we evaluate human subjects’ ability to continuously modulate their motor behavior based on feedback from direct surface stimulation of the somatosensory cortex. Subjects wore a dataglove that measured their hand aperture position and received one of three stimuli over the hand sensory cortex based on their current hand position as compared to a target aperture position. Using cortical stimulation feedback, subjects adjusted their hand aperture to move towards the target aperture region. One subject was able to achieve accuracies and R2 values well above chance (best performance: R2 = 0.93; accuracy = 0.76/1). Performance dropped during the catch trial (same stimulus independent of the position) to below chance levels, suggesting that the subject had been using the varied sensory feedback to modulate their motor behavior. To our knowledge, this study represents one of the first demonstrations of using direct cortical surface stimulation of the human sensory cortex to perform a motor task, and is a first step towards developing closed-loop human sensorimotor brain-computer interfaces.