From molecular to modular cell biology
From molecular to modular cell biology
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DOI：
10.1038/35011540
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发表时间：
1999-12-02
期刊：
影响因子：
64.8
通讯作者：
Murray, AW
中科院分区：
文献类型：
--
作者：
Hartwell, LH;Hopfield, JJ;Murray, AW
细胞功能，如信号传输，是由许多相互作用的分子组成的“模块”进行的，理解模块如何工作取决于将现象学分析与分子研究相结合。控制模块的结构和行为的一般原则可以在工程和计算机科学等合成科学的帮助下发现，从细胞生物学实验和理论之间更强的相互作用中，以及从对进化约束的理解中发现。
Cellular functions, such as signal transmission, are carried out by 'modules' made up of many species of interacting molecules, Understanding how modules work has depended on combining phenomenological analysis with molecular studies. General principles that govern the structure and behaviour of modules may be discovered with help from synthetic sciences such as engineering and computer science, from stronger interactions between experiment and theory in cell biology, and from an appreciation of evolutionary constraints.