Expression pattern of the C-elegans p21-activated protein kinase, CePAK
Expression pattern of the C-elegans p21-activated protein kinase, CePAK
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DOI：
10.1006/bbrc.1998.8380
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发表时间：
1998-04-07
影响因子：
3.1
通讯作者：
Yamamoto, M
中科院分区：
文献类型：
--
作者：
Iino, Y;Yamamoto, M
秀丽隐杆线虫p21活化蛋白激酶（CePAK）与哺乳动物的PAKs具有高度的氨基酸序列相似性。利用lacZ和绿色荧光蛋白（GFP）报告基因检测了CePAK表达的组织特异性。该分析表明，CePAK主要在咽部肌肉、CAN神经元以及腹神经索中的运动神经元中表达，也在尾部区域的一些细胞和远端顶端细胞中表达。CePAK - GFP融合蛋白优先定位于咽部肌肉的细胞表面。（C）1998年学术出版社。
The C. elegans p21-activated protein kinase (CePAK) has a high amino-acid sequence similarity to mammalian PAKs. Tissue specificity of the expression of CePAK was examined using lacZ and GFP reporters. This analysis indicated that CePAK is expressed mainly in pharyngeal muscles, the CAN neurons, and motor neurons in the ventral nerve cord, as well as several cells in the tail region and the distal tip cells. The CePAK::GFP fusion protein was preferentially localized to the cell surface in pharyngeal muscles. (C) 1998 Academic Press.