Eph receptors and ephrin signaling pathways: a role in bone homeostasis.
Eph receptors and ephrin signaling pathways: a role in bone homeostasis.
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DOI：
10.7150/ijms.5.263
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发表时间：
2008-09-03
影响因子：
3.6
通讯作者：
Mundy GR
中科院分区：
文献类型：
--
作者：
Edwards CM;Mundy GR
骨稳态的维持受到严格控制，很大程度上依赖于破骨细胞和成骨细胞之间的细胞通讯，以及骨吸收与骨形成的耦合。这种紧密耦合对于骨骼系统的正确功能和维护，修复微观骨骼损伤和替换老化骨骼至关重要。一系列病理性疾病，包括骨质疏松症和癌症引起的骨病，会破坏这种耦合并导致随后的骨稳态改变。Eph受体及其相关配体ephrin在许多细胞过程中发挥关键作用，包括免疫调节、神经元发育和癌症转移。Eph受体也在骨髓微环境中发现的细胞中表达，包括破骨细胞和成骨细胞，并且越来越多的证据表明该受体家族控制正常和病理骨重塑。
The maintenance of bone homeostasis is tightly controlled, and largely dependent upon cellular communication between osteoclasts and osteoblasts, and the coupling of bone resorption to bone formation. This tight coupling is essential for the correct function and maintenance of the skeletal system, repairing microscopic skeletal damage and replacing aged bone. A range of pathologic diseases, including osteoporosis and cancer-induced bone disease, disrupt this coupling and cause subsequent alterations in bone homeostasis. Eph receptors and their associated ligands, ephrins, play critical roles in a number of cellular processes including immune regulation, neuronal development and cancer metastasis. Eph receptors are also expressed by cells found within the bone marrow microenvironment, including osteoclasts and osteoblasts, and there is increasing evidence to implicate this family of receptors in the control of normal and pathological bone remodeling.