Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children
Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children
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DOI：
10.1371/journal.pone.0086448
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发表时间：
2014-02-03
期刊：
影响因子：
3.7
通讯作者：
Madhi, Shabir A.
中科院分区：
文献类型：
--
作者：
Nunes, Marta C.;Kuschner, Zachary;Madhi, Shabir A.
背景：分子诊断学的进展提示新发现的呼吸道病毒与肺炎的发病机制有关。本研究旨在了解住院下呼吸道感染（LRTI）患儿中人博病毒（hBoV）、人鼻病毒（hRV）、多瘤病毒- wu （WUPyV）和-KI （KIPyV）以及人冠状病毒(CoV)-OC43、-NL63、-HKU1和-229E的流行情况和临床特征。方法：对存档的hiv感染和未感染儿童的鼻咽吸入液进行多重实时逆转录酶聚合酶链反应(
Background: Advances in molecular diagnostics have implicated newly-discovered respiratory viruses in the pathogenesis of pneumonia. We aimed to determine the prevalence and clinical characteristics of human bocavirus (hBoV), human rhinovirus (hRV), polyomavirus-WU (WUPyV) and -KI (KIPyV) and human coronaviruses (CoV)-OC43, -NL63, -HKU1 and -229E among children hospitalized with lower respiratory tract infections (LRTI).Methods: Multiplex real-time reverse-transcriptase polymerase chain reaction was undertaken on archived nasopharyngeal aspirates from HIV-infected and -uninfected children (