POLYMORPHISM OF MAJOR ENVELOPE GLYCOPROTEIN (GP70) OF MURINE C-TYPE VIRUSES - VIRION ASSOCIATED AND DIFFERENTIATION ANTIGENS ENCODED BY A MULTI-GENE FAMILY
POLYMORPHISM OF MAJOR ENVELOPE GLYCOPROTEIN (GP70) OF MURINE C-TYPE VIRUSES - VIRION ASSOCIATED AND DIFFERENTIATION ANTIGENS ENCODED BY A MULTI-GENE FAMILY
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DOI：
10.1038/267023a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
LERNER, RA
中科院分区：
文献类型：
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作者：
ELDER, JH;JENSEN, FC;LERNER, RA
对35种不同的小鼠C型病毒主要包膜糖蛋白(Gp70)和在小鼠不同解剖部位表达的游离gp70的结构比较表明，gp70是一个携带病毒和分化抗原的多基因大家族的多态产物。不同的前病毒按照不同的分化途径在[小鼠、大鼠和兔]细胞中表达。当各种gp70根据一级结构分组时，它们自然落入病毒宿主范围类别，表明C型病毒的嗜性在很大程度上由所表达的gp70产物的性质决定。
Structural comparison of the major envelope glycoproteins (gp70) from 35 different murine type C viruses and free gp70 expressed at various anatomical sites in the mouse showed that the gp70 are polymorphic products of a large multi-gene family endocing viral and differentiation antigens. Different proviruses are expressed in [mouse, rat and rabbit] cells following distinct pathways of differentiation. When the various gp70 are grouped according to primary structure they fall naturally into viral host range classes, indicating that C-type viral tropism is largely determined by the nature of the gp70 product expressed.