Rhodium(I)-Catalyzed Intermolecular [2+2+2] Cycloaddition of Allenyl Aldehydes with Alkynes and Related Cyclization
Rhodium(I)-Catalyzed Intermolecular [2+2+2] Cycloaddition of Allenyl Aldehydes with Alkynes and Related Cyclization
复制标题
铑(I)催化的分子间[2 2 2]烯醛与炔烃的环加成及相关环化
DOI：
10.1002/ajoc.201402239
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yoshihiro Sato
中科院分区：
文献类型：
--
作者：
Yoshihiro Oonishi;Akira Saito;Yoshihiro Sato
研究了铑（I）催化联烯醛与各种炔的环化反应。具有富电子芳环和末端吸电子基团的内炔的环化以良好的产率提供[2+2+2]环加成产物，具有良好到高的区域和对映选择性，而末端炔的反应以良好的产率得到二烯基酮而不是[2+2+2]环加成产物。这些结果表明，炔的性质对反应过程有很大的影响。
Rhodium(I)‐catalyzed cyclization of allenyl aldehydes with various alkynes was investigated. The cyclizations of internal alkynes that have both an electron‐rich aromatic ring and an electron‐withdrawing group at the terminus afforded [2+2+2] cycloaddition products in good yields with good to high regio‐ and enantioselectivity, while the reactions of terminal alkynes gave dienyl ketones instead of [2+2+2] cycloaddition products in good yields. These results indicate that the nature of the alkynes greatly influences the reaction course.