Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine
Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine
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DOI：
10.1080/15563650903059136
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发表时间：
2009-01-01
影响因子：
3.3
通讯作者：
Chau, Tai Nin
中科院分区：
文献类型：
--
作者：
Cheung, Wing I.;Tse, Man Li;Chau, Tai Nin
枸杞子（FP）被中医用于治疗绝经后骨质疏松症、白癜风和银屑病。它单独使用，或与其他草药结合使用，在一些国家以专利药的形式使用。它被认为是一种新兴的肝毒素，在这里我们报告了三例急性肝炎后，暴露于FP及其相关的专利药物。看来，补骨脂素及其相关化学物质可能是肝毒性的原因。与其他药物配伍，毒性成分浓度增高，肝损伤加重。总之，FP与某些个体的肝毒性相关。对草药产品的潜在副作用进行药物警戒是必要的。
Fructus Psoraleae (FP) is used by herbalists for the treatment of postmenopausal osteoporosis, vitiligo, and psoriasis. It is used alone, or in combination with other herbs, in some countries in the form of proprietary medicine. It is recognized as one of the emerging hepatotoxins and here we report three cases of acute hepatitis after exposed to FP and its related proprietary medicine. It seems possible that psoralen and its related chemicals may be responsible for the hepatotoxicity. Decoction with other herbs may result in higher concentration of toxic constituents and in more severe liver injury. In summary, FP is associated with hepatotoxicity in some individuals. Pharmacovigilance for the potential side effects of herbal products is necessary.