Five versus three days of ofloxacin therapy for traveler's diarrhea: a placebo-controlled study.
Five versus three days of ofloxacin therapy for traveler's diarrhea: a placebo-controlled study.
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五天与三天的氧氟沙星治疗旅行者腹泻：一项安慰剂对照研究。
DOI：
10.1128/aac.36.1.87
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发表时间：
1992
影响因子：
4.9
通讯作者：
DuPont,MW
中科院分区：
文献类型：
--
作者：
DuPont,HL;Ericsson,CD;Mathewson,JJ;DuPont,MW
在这项双盲研究中，232名患者，300毫克的氧氟沙星口服给药，每天两次，连续5或3天，与安慰剂相比，用于治疗访问墨西哥瓜达拉哈拉的美国学生的急性腹泻。发现氧氟沙星3天方案在产生临床和微生物学治愈方面与5天方案一样有效。接受氧氟沙星5天的患者中有59例（89%）临床治愈，而接受氧氟沙星3天的患者中有77例（95%）临床治愈，安慰剂组中有56例（71%）临床治愈（P = 0.0001）。当治疗开始后腹泻的持续时间在亚组中进行比较时，与安慰剂组相比，以下各组治疗后疾病发生时间缩短（P <0.05）：氧氟沙星治疗5天，（32 vs 98 h）;氧氟沙星3天，所有病例（28 vs 56 h），肠源性大肠埃希菌腹泻病例（26 vs 66 h），志贺氏菌病病例（24 vs 98 h），所有与细菌性肠道病原体相关的疾病病例（28 vs 69 h），以及通过显微镜检查在粪便中发现大量白细胞的病例（22 vs 49 h）。氧氟沙星组78例患者中有75例（96%）的微生物根除率，安慰剂组46例患者中有37例（80%）的微生物根除率（P = 0.009）。两个治疗组中患者报告的不良事件数量无显著差异。（250字处删节）
In this double-blind study with 232 patients, 300 mg of ofloxacin given orally twice daily for 5 or 3 days was compared with placebo for the treatment of acute diarrhea in U.S. students visiting Guadalajara, Mexico. The 3-day regimen of ofloxacin was found to be as effective as the 5-day regimen in producing a clinical and microbiologic cure. Clinical cures for patients who received ofloxacin for 5 days occurred in 59 of 66 (89%) subjects, whereas clinical cure occurred in 77 of 81 (95%) of those who received ofloxacin for 3 days and in 56 of 79 (71%) of those who took placebo (P = 0.0001). When the duration of diarrhea after therapy was begun was compared in subgroups, a significant (P less than 0.05) shortening of posttreatment illness occurred in comparison with that in the placebo group for the following groups: for 5 days of ofloxacin, cases of shigellosis (32 versus 98 h); for 3 days of ofloxacin, all cases (28 versus 56 h), cases of enterotoxigenic Escherichia coli diarrhea (26 versus 66 h), cases of shigellosis (24 versus 98 h), all cases of illnesses associated with a bacterial enteropathogen (28 versus 69 h), and cases of illnesses in which numerous leukocytes were found in stool by microscopy (22 versus 49 h). Microbiologic eradication rates were 75 of 78 (96%) for patients who received ofloxacin and 37 of 46 (80%) for patients who received placebo (P = 0.009). There was no significant difference in the number of adverse events reported by patients in either of the treatment groups.(ABSTRACT TRUNCATED AT 250 WORDS)