Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris
Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris
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DOI：
10.1055/s-2000-8531
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发表时间：
2000-05-01
期刊：
影响因子：
2.7
通讯作者：
Kim, KM
中科院分区：
文献类型：
--
作者：
Ryu, SY;Oak, MH;Kim, KM
通过活性引导分离得到白桦酸、熊果酸、2 α、3 α -二羟基-12-烯-28-酸、2 α -羟基熊果酸4种三萜。其中一种化合物，2 α，3 α -二羟基熊果酸，对培养的RBL-2H3细胞释放β -己糖氨酸酶表现出明显的抑制作用，且呈剂量依赖性；对分离得到的化合物对小鼠巨噬细胞产生一氧化氮的影响进行了IC50值为57 μ M，结果表明，熊果酸和2 α -羟基熊果酸表现出较强的抑制活性（IC50值分别为17 μ M和27 μ M）。
The activity-guided fractionation of the extract of the herb of Prunello vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic acid, and 2 alpha-hydroxyursolic acid. One of these compounds, 2 alpha,3 alpha-dihydroxyursolic acid, demonstrated significant inhibition on the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner; the IC50 value was calculated to be 57 mu M. When the isolated compounds were tested for their effects on the production of nitric oxide from cultured murine macrophages, RAW 264.7 cells, ursolic acid and 2 alpha-hydroxyursolic acid exhibited strong inhibitory activities (IC50 values, 17 and 27 mu M, respectively).