Solvent-Assisted Self-Assembly of a Metal-Organic Framework Based Biocatalyst for Cascade Reaction Driven Photodynamic Therapy
Solvent-Assisted Self-Assembly of a Metal-Organic Framework Based Biocatalyst for Cascade Reaction Driven Photodynamic Therapy
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DOI：
10.1021/jacs.0c02497
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发表时间：
2020-04-08
影响因子：
15
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
He, Liangcan;Ni, Qianqian;Chen, Xiaoyuan
活细胞中的生物催化反应涉及空间受限的微环境中的复杂转变。受生物转化过程的启发，我们通过将人工酶（超小Au纳米颗粒）与上转换纳米颗粒（NaYF4@NaYb0.92F4：Er-0.08@NaYF4）锆/铁卟啉金属有机框架核壳纳米颗粒（UMOF NPs）整合，在荷瘤小鼠中展示了有效的生物催化级联驱动的光动力学疗法，所述纳米颗粒充当生物催化剂和纳米反应器。核壳结构的UMOF纳米粒子的构建是通过一种独特的“溶剂辅助自组装”方法实现的。超小AuNP在UMOFs基质上的整合导致葡萄糖耗尽，通过葡萄糖氧化酶样催化活性提供Au介导的癌症治疗。同时，UMOF基质通过在照射时经由过氧化氢分解连续供应氧而充当近红外（NIR）光光子激活的单线态氧发生器。这类生物催化剂为生物医学、催化和能源应用提供了令人兴奋的机会。
Biocatalytic reactions in living cells involve complex transformations in the spatially confined microenvironments. Inspired by biological transformation processes, we demonstrate effective biocatalytic cascade driven photodynamic therapy in tumor-bearing mice by the integration of an artificial enzyme (ultrasmall Au nanoparticles) with upconversion nanoparticles (NaYF4@NaYb0.92F4:Er-0.08@NaYF4)zirconium/iron porphyrin metal-organic framework core-shell nanoparticles (UMOF NPs) which act as biocatalysts and nanoreactors. The construction of core-shell UMOF NPs are realized by using a unique "solvent-assisted self-assembly" method. The integration of ultrasmall AuNPs on the UMOFs matrix leads to glucose depletion, providing Au-mediated cancer therapy via glucose oxidase like catalytic activity. Meanwhile, the UMOF matrix acts as a near-infrared (NIR) light photon-activated singlet oxygen generator through a continuous supply of oxygen via hydrogen peroxide decomposition upon irradiation. Such kinds of biocatalysts offer exciting opportunities for biomedical, catalytical,and energy applications.