Virus Budding
Virus Budding
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病毒出芽
DOI：
10.1016/b978-0-12-814515-9.00023-0
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发表时间：
2021-03-01
期刊：
影响因子：
--
通讯作者：
Sundquist WI
中科院分区：
文献类型：
--
作者：
Rheinemann L;Sundquist WI
包膜病毒离开生产细胞，通过限制性细胞膜出芽获得其外部脂质包膜。大多数病毒编码多功能结构蛋白，其协调病毒体组装、膜形成、出芽和成熟的过程。在许多情况下，细胞ESCRT途径被募集以促进出芽的膜分裂步骤，但也采用替代策略。最近，许多以前被认为是无包膜的病毒已被证明在囊泡内以非裂解方式离开细胞，这进一步增加了病毒出芽和外出的复杂性。
Enveloped viruses exit producer cells and acquire their external lipid envelopes by budding through limiting cellular membranes. Most viruses encode multifunctional structural proteins that coordinate the processes of virion assembly, membrane envelopment, budding, and maturation. In many cases, the cellular ESCRT pathway is recruited to facilitate the membrane fission step of budding, but alternative strategies are also employed. Recently, many viruses previously considered to be non-enveloped have been shown to exit cells non-lytically within vesicles, adding further complexity to the intricacies of virus budding and egress.