The mechanism of amphetamine-induced loss of weight; a consideration of the theory of hunger and appetite.
The mechanism of amphetamine-induced loss of weight; a consideration of the theory of hunger and appetite.
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安非他明引起的体重减轻的机制；
DOI：
10.1001/jama.1947.02880340022005
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发表时间：
1947
影响因子：
--
通讯作者：
L. Searle
中科院分区：
文献类型：
--
作者：
S. Harris;A. Ivy;L. Searle
人们普遍认为，服用安非他明（“苯丙胺”）有助于减轻体重。该药物的这种作用于 1937 年首次被报道，当时观察到出于其他目的而服用安非他明的患者体重减轻。 1 从那时起，出现了许多论文，其中报道该药物在治疗肥胖方面具有价值。 2 然而，对照实验尚未证明该药物确实能减轻体重。该药物明显促进减肥的机制尚未确定。所有可能的机制都已在文献中提出，并总结在以下概述中。该药物可促进减肥：通过增加基础代谢（如二硝基苯酚）来增加能量消耗，或通过增加肌肉活动来增加能量消耗
It is generally agreed that the administration of amphetamine ("benzedrine") facilitates the reduction of weight. This effect of the drug was first reported in 1937, when patients receiving amphetamine for other purposes were observed to lose weight. 1 Since that time a number of papers have appeared in which the drug has been reported to be of value in the management of obesity. 2 However, it has not been demonstrated by controlled experiments that the drug actually causes a reduction of body weight. The mechanism by which the drug apparently facilitates the loss of weight has not been settled. All the possible mechanisms have been suggested in the literature and are summarized in the following outline. The drug acts to facilitate the loss of weight: By increasing the expenditure of energy by increasing the basal metabolism as does dinitrophenol or by increasing muscular activity by