Mutations in ribosomal proteins and ribosomal RNA confer macrolide resistance in human Ureaplasma spp.
Mutations in ribosomal proteins and ribosomal RNA confer macrolide resistance in human Ureaplasma spp.
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DOI：
10.1016/j.ijantimicag.2010.12.012
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发表时间：
2011-04
影响因子：
10.8
通讯作者：
Li Xiao;D. Crabb;L. Duffy;V. Paralanov;J. Glass;D. Hamilos;K. Waites
中科院分区：
文献类型：
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作者：
Li Xiao;D. Crabb;L. Duffy;V. Paralanov;J. Glass;D. Hamilos;K. Waites
对6株解脲支原体大环内酯类抗生素耐药的遗传机制进行了研究。红霉素最低抑菌浓度(MIC)为8μg/m L。23S rRNA V区的点突变和/或核糖体蛋白L4基因的突变可能是导致这种耐药性的原因。总体而言，大环内酯类耐药不常见，而四环素耐药在121个单独分离株中记录在案(33%)。
Genetic mechanisms of macrolide resistance were investigated in six isolates of Ureaplasma spp. with erythromycin minimum inhibitory concentrations (MICs)≥8μg/mL that were derived from 370 cultures obtained over a several year period. Point mutations in domain V of 23S rRNA and/or mutations in ribosomal protein L4 genes are likely to be responsible for this drug resistance. Overall, macrolide resistance was uncommon, in contrast to tetracycline resistance that was documented in 121 unique isolates (33%).