Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome - A summary of the evidence
Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome - A summary of the evidence
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DOI：
10.2337/diacare.28.7.1769
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发表时间：
2005-07-01
期刊：
影响因子：
16.2
通讯作者：
Ford, ES
中科院分区：
文献类型：
--
作者：
Ford, ES
目的--近年来，几个主要的组织已经认可了代谢综合征的概念，并为它制定了工作定义，这些定义在预测代谢综合征患者不良事件风险方面的效果如何，现在才被了解。本研究的目的是总结全因死亡率、心血管疾病、和糖尿病的前瞻性研究报告的样本来自一般人群使用的定义的代谢综合征开发的国家胆固醇教育计划（NCEP）和世界卫生组织（WHO）。作者回顾了1998年7月至2004年8月的前瞻性研究。结果-对于使用NCEP代谢综合征确切定义的研究，全因死亡率、心血管疾病和糖尿病的合并相对危险度的随机效应估计值分别为1.27（95%CI 0.90-1.78）、1.65（1.38 -1.99）和2.99（1.96-4.57）。对于使用最准确的WHO代谢综合征定义的研究，相对危险度的固定效应估计值为1.37（1.09-1.74）全因死亡率和1.93（1.39-2.67）对于心血管疾病，固定效应估计值为2.60（1.55-4.38）对于冠心病。结论-这些估计表明，代谢综合征的人群归因分数，如目前所设想的，与全因死亡率的6-7%相似，12-17%为心血管疾病，30-52%为糖尿病。需要进一步的研究来确定代谢综合征在预测不同人群亚群的死亡、心血管疾病和糖尿病风险中的应用。
OBJECTIVE - in recent years, several major organizations have endorsed the concept of the metabolic syndrome and developed working definitions for it. How well these definitions predict the risk for adverse events in people, with the metabolic syndrome is only now being learned. The purpose of this study was to summarize the estimates of relative risk for all-cause mortality, cardiovascular disease, and diabetes reported from prospective studies in samples from the general population Using definitions of the metabolic syndrome developed by the National Cholesterol Education Program (NCEP) and World Health Organization (WHO).RESEARCH DESIGN AND METHODS - The author reviewed prospective studies from July 1998 through August 2004.RESULTS - For studies that used the exact NCEP definition of the metabolic syndrome, random-effects estimates of combined relative risk were 1.27 (95% CI 0.90-1.78) for all-cause mortality, 1.65 (1,38-1.99) for cardiovascular disease, and 2.99 (1.96-4.57) for diabetes. For studies that used the most exact WHO definition of the metabolic syndrome, the fixed-effects estimates of relative risk were 1.37 (1.09-1.74) for-all-cause mortality and 1.93 (1.39-2.67) for cardiovascular diseased the fixed-effects estimate was 2.60 (1.55-4.38) for coronary heart disease.CONCLUSIONS - These estimates Suggest that the population-attributable fraction for the metabolic syndrome, as it is currently conceived, is similar to 6-7% for all-cause mortality, 12-17% for cardiovascular disease, and 30-52% for diabetes. Further research is needed to establish the use of the metabolic syndrome in predicting risk for death, cardiovascular disease, and diabetes in various population subgroups.