Verb generation in patients with focal frontal lesions: a neuropsychological test of neuroimaging findings.
Verb generation in patients with focal frontal lesions: a neuropsychological test of neuroimaging findings.
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DOI：
10.1073/pnas.95.26.15855
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发表时间：
1998-12
影响因子：
11.1
通讯作者：
S. Thompson-Schill;D. Swick;M. Farah;M. D’Esposito;Irene P. Kan;R. Knight
中科院分区：
文献类型：
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作者：
S. Thompson-Schill;D. Swick;M. Farah;M. D’Esposito;Irene P. Kan;R. Knight
语义记忆的神经基础是什么？传统的观点认为，颞叶有助于检索语义知识，所产生的病变的研究，最近已被质疑的功能性神经影像学研究发现语义检索和活动之间的相关性，在左前额叶皮层。神经影像学是否教会了我们一些旧方法无法揭示的认知神经基础的新东西，或者它只是识别了与语义提取过程相关但没有因果关系的大脑活动？我们研究了额叶局灶性病变患者执行神经影像学实验中常用任务的能力，即为具体名词生成语义上合适的动作词，并发现了左额下回对动词生成任务某些组成部分的必要性的证据。值得注意的是，这些组件本身并不包括语义检索。
What are the neural bases of semantic memory? Traditional beliefs that the temporal lobes subserve the retrieval of semantic knowledge, arising from lesion studies, have been recently called into question by functional neuroimaging studies finding correlations between semantic retrieval and activity in left prefrontal cortex. Has neuroimaging taught us something new about the neural bases of cognition that older methods could not reveal or has it merely identified brain activity that is correlated with but not causally related to the process of semantic retrieval? We examined the ability of patients with focal frontal lesions to perform a task commonly used in neuroimaging experiments, the generation of semantically appropriate action words for concrete nouns, and found evidence of the necessity of the left inferior frontal gyrus for certain components of the verb generation task. Notably, these components did not include semantic retrieval per se.