Chemokine-induced fever: intracerebroventricular actions of MIP-1 and MIP-1 alpha in rats.
Chemokine-induced fever: intracerebroventricular actions of MIP-1 and MIP-1 alpha in rats.
复制标题
趋化因子诱导的发热：MIP-1 和 MIP-1 α 在大鼠脑室内的作用。
DOI：
10.1097/00001756-199406270-00018
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发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
Myers,RD
中科院分区：
文献类型：
--
作者：
Zawada,WM;Ruwe,WD;Clarke,J;Wall,PT;Myers,RD
：通过脑室内输注测定双联体巨噬细胞炎症蛋白-1 (MIP-1) 和 MIP-1α 在大鼠中的中枢致热作用。将560pg和11.2ng的MIP-1或10.0ng的MIP-1α剂量注入第三脑室引起长期持续的发热。然而，MIP-1α在强度和较长潜伏期方面比MIP-1弱得多。总体而言，这些细胞因子作用于第三脑室壁时会产生热原性。然而，根据早期实验，需要比直接注射到下丘脑前部的剂量大 10 倍才能引起发烧。最后，循环中的 MIP-1 可以通过脉络丛进入脑室系统发挥中枢作用。
: The central pyrogenic actions in the rat of doublet macrophage inflammatory protein-1 (MIP-1) and MIP-1 [alpha] were determined by their intracerebroventricular infusion. Doses of 560 pg and 11.2 ng of MIP-1 or 10.0 ng MIP-1 [alpha] infused into the third cerebral ventricle induced a long lasting fever. However, MIP-1 [alpha] was much less potent than MIP-1 in terms of intensity and longer latency. Overall, these cytokines are pyrogenic when acting on the walls of the third ventricle; however, a dose 10 times greater than that injected directly into the anterior hypothalamus is required to evoke fever, as based on earlier experiments. Finally, circulating MIP-1 could act centrally by its entry through the choroid plexus into the ventricular system of the brain.