Hypopituitarism After Traumatic Brain Injury
Hypopituitarism After Traumatic Brain Injury
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DOI：
10.1016/j.ecl.2014.10.012
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发表时间：
2015-03-01
影响因子：
4.5
通讯作者：
Casanueva, Felipe F.
中科院分区：
文献类型：
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作者：
Fernandez-Rodriguez, Eva;Bernabeu, Ignacio;Casanueva, Felipe F.
创伤性脑损伤（TBI）后垂体功能减退的患病率在文献中有很大差异;荟萃分析确定前垂体功能减退的合并患病率为27.5%。生长激素缺乏症是TBI后最常见的激素不足;然而，每种类型的垂体缺乏症的患病率受用于诊断的测定，头部创伤的严重程度和评估时间的影响。最近的研究表明，TBI后GH缺乏患者的认知功能和认知生活质量与替代治疗的改善。
The prevalence of hypopituitarism after traumatic brain (TBI) injury is widely variable in the literature; a meta-analysis determined a pooled prevalence of anterior hypopituitarism of 27.5%. Growth hormone deficiency is the most prevalent hormone insufficiency after TBI; however, the prevalence of each type of pituitary deficiency is influenced by the assays used for diagnosis, severity of head trauma, and time of evaluation. Recent studies have demonstrated improvement in cognitive function and cognitive quality of life with substitution therapy in GH-deficient patients after TBI.