Brain mitochondrial dysfunction as a link between Alzheimer's!disease and diabetes
Brain mitochondrial dysfunction as a link between Alzheimer's!disease and diabetes
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DOI：
10.1016/j.jns.2007.01.017
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发表时间：
2007-06-15
影响因子：
4.4
通讯作者：
Oliveira, Catarina R.
中科院分区：
文献类型：
--
作者：
Moreira, Paula I.;Santos, Maria S.;Oliveira, Catarina R.
有人认为，在迟发性阿尔茨海默病中，神经元葡萄糖代谢控制的紊乱，从而导致胰岛素信号传导受损，这与非神经组织中2型糖尿病的病理生理学非常相似。事实上，线粒体是活性氧的主要产生者和直接靶点，导致几位研究人员提出线粒体中的氧化应激和损伤是包括阿尔茨海默病和糖尿病在内的几种疾病的促成因素。由于脑具有高能量需求，脑线粒体电子链的任何下降都可能对脑功能产生严重影响，特别是对神经退行性疾病的病因产生严重影响。这篇综述主要集中在讨论脑线粒体功能障碍作为糖尿病和阿尔茨海默病之间的联系。(c)2007 Elsevier B.V.保留所有权利。
It has been argued that in late-onset Alzheimer's disease a disturbance in the control of neuronal glucose metabolism consequent to impaired insulin signalling strongly resembles the pathophysiology of type 2 diabetes in non-neural tissue. The fact that mitochondria are the major generators and direct targets of reactive oxygen species led several investigators to foster the idea that oxidative stress and damage in mitochondria are contributory factors to several disorders including Alzheimer's disease and diabetes. Since brain possesses high energetic requirements, any decline in brain mitochondria electron chain could have a severe impact on brain function and particularly on the etiology of neurodegenerative diseases. This review is primarily focused in the discussion of brain mitochondrial dysfunction as a link between diabetes and Alzheimer's disease. (c) 2007 Elsevier B.V. All rights reserved.