Risk factors for fibrocystic breast disease and its histopathologic components.
Risk factors for fibrocystic breast disease and its histopathologic components.
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DOI：
10.1093/jnci/75.1.43
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发表时间：
1985-07
期刊：
影响因子：
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通讯作者：
G. Berkowitz;J. Kelsey;V. Livolsi;T. Holford;M. Merino;S. Ort;T. O'Connor;C. White
中科院分区：
文献类型：
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作者：
G. Berkowitz;J. Kelsey;V. Livolsi;T. Holford;M. Merino;S. Ort;T. O'Connor;C. White
1979年至1981年，在康涅狄格州的五家医院进行了一项病例对照研究，评价了各种社会人口学、生殖和其他因素与纤维囊性乳腺病发生之间的关系。研究组包括590名经活检证实患有纤维囊性乳腺疾病的妇女和1，018名患有其他手术条件的妇女。在绝经前妇女中，多变量分析表明，高社会经济地位、犹太宗教、低产次、良性乳腺疾病史、母亲或姐妹乳腺癌史以及低克托莱指数与纤维囊性乳腺病的比值比（OR）增加相关。对绝经后女性的类似分析显示，社会经济地位高、绝经年龄晚和有良性乳腺疾病史的女性的OR增加。目前的吸烟者以及那些做过输卵管绝育手术的人患纤维囊性疾病的几率显著降低。没有令人信服的证据表明，根据上皮细胞增生的程度，任何考虑的变量的线性趋势。尽管根据所选的组织学成分，分析中出现了OR的一些变化，但结果几乎没有证据表明活检标本显示肉眼囊肿、硬化性腺病、乳头状增生或乳头状瘤病的女性与乳腺癌患者在流行病学上相似。
The relationship between various sociodemographic, reproductive, and other factors to the occurrence of fibrocystic breast disease was evaluated in a case-control study undertaken at five Connecticut hospitals from 1979 to 1981. The study groups comprised 590 women with biopsy-proven fibrocystic breast disease and 1,018 women with other surgical conditions. Among the premenopausal women, multivariate analysis suggested that high socioeconomic status, Jewish religion, low parity, a history of benign breast disease, a history of breast cancer in the mother or a sister, and low Quetelet index were associated with increased odds ratios (OR) for fibrocystic breast disease. Similar analysis for the postmenopausal women revealed increased OR for women with high socioeconomic status, a late age at menopause, and a history of benign breast disease. Current smokers as well as those who had had a tubal sterilization had significantly reduced odds of fibrocystic disease. There was no convincing evidence of linear trends according to degree of epithelial atypia for any of the variables considered. Although some variation in the OR emerged in the analysis according to selected histologic components, the results provided little evidence that women with biopsy specimens exhibiting gross cysts, sclerosing adenosis, papillary hyperplasia, or papillomatosis showed epidemiologic similarities with breast cancer patients.