Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial
Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial
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DOI：
10.1016/j.nut.2015.10.014
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发表时间：
2016-04-01
期刊：
影响因子：
4.4
通讯作者：
Lim, Do-Sun
中科院分区：
文献类型：
--
作者：
Jeong, Han Saem;Hong, Soon Jun;Lim, Do-Sun
目的：乌藨子具有改善血管功能的作用。然而，还没有研究评估其对高血压前期患者24小时收缩压和舒张压的影响。本研究的目的是检查这些effects.Methods：将高血压前期患者（N = 45）前瞻性随机分为中等剂量黑树莓组（n = 15，1500 mg/d），高剂量黑树莓组（n = 15，2500 mg/d），或安慰剂组（n = 15）在8周的随访期间。乌藨子以干燥粉末提取物的形式食用，并制成胶囊。胶囊含有187.5和312.5毫克乌藨子粉，相当于1500和2500毫克乌藨子。在基线和8周随访时测量24小时动态血压（BP）;中心BP;脉搏波速度;腹部内脏脂肪;血清肾素;血管紧张素转换酶;和炎性细胞因子，如白细胞介素-6、肿瘤坏死因子-α、C反应蛋白、可溶性细胞间粘附分子1、可溶性血管细胞粘附分子-1和纤溶酶原激活物抑制剂-1。在8周的随访中，与对照组相比，高剂量的黑树莓显著降低了24小时收缩压（SBP; 3.3 +/- 10 mm Hg vs-6.7 +/- 11.8 mm Hg; P < 0.05）和夜间SBP（5.4 +/- 10.6 mm Hg vs-4.5 +/- 11.3 mm Hg; P < 0.05）。黑树莓粉没有产生任何显着的变化，在大多数的参数比BP.Conclusion：使用黑树莓显着降低24小时血压在8周的随访高血压前期患者。黑树莓作为膳食补充剂可能有助于降低高血压前期患者的SBP。(C)2016 Elsevier Inc. All rights reserved.
Objective: Black raspberry (Rubus occidentalis) is known for improving vascular function. However, there has been no study evaluating its effects on 24-h systolic and diastolic blood pressure in prehypertensive patients. The aim of this study was to examine those effects.Methods: Patients with prehypertension (N = 45) were prospectively randomized into a moderate dose black raspberry group (n = 15, 1500 mg/d), a high-dose black raspberry group (n = 15, 2500 mg/d), or a placebo group (n = 15) during an 8-wk follow-up period. Raspberries were consumed in the form of a dried powder extract that was fashioned into capsules. The capsules contained 187.5 and 312.5 mg of raspberry powder, which was equivalent to 1500 and 2500 mg raspberries. Ambulatory 24-h blood pressure (BP); central BP; pulse-wave velocity; abdominal visceral fat; serum renin; angiotensin-converting enzyme; and inflammatory cytokines such as interleukin-6, tumor necrosis factor-alpha, C-reactive protein, soluble intercellular adhesion molecule 1, soluble vascular cell adhesion molecule-1, and plasminogen activator inhibitor-1 were measured at baseline and at 8-wk follow-up.Results: High-dose black raspberry significantly reduced 24-h systolic blood pressure (SBP; 3.3 +/- 10 mm Hg versus -6.7 +/- 11.8 mm Hg; P < 0.05) and nighttime SBP (5.4 +/- 10.6 mm Hg versus -4.5 +/- 11.3 mm Hg; P < 0.05) compared with controls during the 8-wk follow-up. Black raspberry powder did not produce any significant changes in most of the parameters other than BP.Conclusion: The use of black raspberry significantly lowered 24-h BP in prehypertensive patients during the 8-wk follow-up. Black raspberry used as a dietary supplement could be beneficial in reducing SBP in prehypertensive patients. (C) 2016 Elsevier Inc. All rights reserved.