The cardiovascular triad of dysfunctional angiogenesis.
The cardiovascular triad of dysfunctional angiogenesis.
复制标题
DOI：
10.1007/s12975-011-0065-5
复制
发表时间：
2011-09-01
影响因子：
6.9
通讯作者：
Badr A
中科院分区：
文献类型：
--
作者：
Zhang J;Carr C;Badr A
脑海绵状血管畸形是一种临床上定义明确的微血管疾病，易患中风；然而，在斑马鱼中观察到的主要表型是心脏缺陷，特别是心脏增大。在探索人类和斑马鱼之间的这种表型差异方面所做的努力较少。鉴于Ccm1/CCM2的基因产物在两个物种中几乎相同，常识表明斑马鱼动物模型将提供一个很好的机会来剖析Ccm1/CCM2在血管形成过程中的详细分子功能。我们最近报道了Ccm1基因在斑马鱼模型中允许适当的血管生成微血管发育的生化过程中的细胞作用。在这项实验的过程中，我们遇到了大量关于斑马鱼血管生成功能障碍与心血管缺陷之间关系的最新研究。在这里，我们将我们的研究结果与这一领域的最新贡献结合起来，并收集关于血管生成缺陷对发育中的心血管系统的影响的结论。我们的结论也为人类和动物模型之间的表型差异提供了一座桥梁，这可能为未来人类中风的翻译研究提供一些启示。
Cerebral cavernous malformation is a clinically well-defined microvascular disorder predisposing to stroke; however, the major phenotype observed in zebrafish is the cardiac defect, specifically an enlarged heart. Less effort has been made to explore this phenotypic discrepancy between human and zebrafish. Given the fact that the gene products from Ccm1/Ccm2 are nearly identical between the two species, the common sense has dictated that the zebrafish animal model would provide a great opportunity to dissect the detailed molecular function of Ccm1/Ccm2 during angiogenesis. We recently reported on the cellular role of the Ccm1 gene in biochemical processes that permit proper angiogenic microvascular development in the zebrafish model. In the course of this experimentation, we encountered a vast amount of recent research on the relationship between dysfunctional angiogenesis and cardiovascular defects in zebrafish. Here we compile the findings of our research with the most recent contributions in this field and glean conclusions about the effect of defective angiogenesis on the developing cardiovascular system. Our conclusion also serves as a bridge for the phenotypic discrepancy between humans and animal models, which might provide some insights into future translational research on human stroke.
登录
查看更多内容
影响因子：
2.7
作者：
Chen, E;Stringer, SE;Ekker, SC
通讯作者：
Ekker, SC
影响因子：
9.2
作者：
Habeck, H;Odenthal, J;Schulte-Merker, S
通讯作者：
Schulte-Merker, S
影响因子：
3.5
作者：
Hogan, Benjamin M.;Bussmann, Jeroen;Schulte-Merker, Stefan
通讯作者：
Schulte-Merker, Stefan
影响因子：
20.3
作者：
Chen, Eleanor;Larson, Jon D.;Ekker, Stephen C.
通讯作者：
Ekker, Stephen C.
脊椎动物心脏传导系统的遗传和生理解剖。
影响因子：
9.8
作者：
Chi NC;Shaw RM;Jungblut B;Huisken J;Ferrer T;Arnaout R;Scott I;Beis D;Xiao T;Baier H;Jan LY;Tristani-Firouzi M;Stainier DY
通讯作者：
Stainier DY