24-h monitoring devices and nyctohemeral rhythms of intraocular pressure
24-h monitoring devices and nyctohemeral rhythms of intraocular pressure
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DOI：
10.1016/j.preteyeres.2016.07.002
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发表时间：
2016-11-01
影响因子：
17.8
通讯作者：
Mansouri, Kaweh
中科院分区：
文献类型：
--
作者：
Aptel, Florent;Weinreb, Robert N.;Mansouri, Kaweh
眼内压（IOP）不是一个固定值，在短期内和持续数月或数年的时间段内都会发生变化。特别是，已知IOP在一天的24小时内变化，定义为人类的昼夜节律。在临床实践中，在几种情况下评估24小时内IOP的变化至关重要，包括高眼压和青光眼的诊断（IOP通常在夜间较高）以及优化青光眼的治疗管理。直到最近，所有24小时IOP节律的评估都是使用重复的IOP测量进行的，需要个体被唤醒进行夜间测量。这种方法可能是不完美的，因为它不是生理的并且干扰睡眠结构，并且还因为它提供了有限数量的时间点测量，不足以精细地评估IOP变化。这些局限性可能使先前对生理性IOP节律的描述存在偏差。最近，已经开发出集成了用于连续IOP监测的压力传感器的眼外和眼内装置，并且可用于人类。本文的目的是介绍这些新的24小时监测设备的昼夜节律的研究的贡献。在健康受试者和未经治疗的青光眼受试者中，始终发现昼夜节律，其特征通常是平均昼夜IOP低于平均夜间IOP，昼夜深相通常在下午中间或结束时，夜间高峰相通常在晚上中间或结束时。(C)2016爱思唯尔有限公司版权所有
Intraocular pressure (IOP) is not a fixed value and varies over both the short term and periods lasting several months or years. In particular, IOP is known to vary throughout the 24-h period of a day, defined as a nyctohemeral rhythm in humans. In clinical practice, it is crucial to evaluate the changes in IOP over 24 h in several situations, including the diagnosis of ocular hypertension and glaucoma (IOP is often higher at night) and to optimize the therapeutic management of glaucoma. Until recently, all evaluations of 24-h IOP rhythm were performed using repeated IOP measurements, requiring individuals to be awakened for nocturnal measurements. This method may be imperfect, because it is not physiologic and disturbs the sleep architecture, and also because it provides a limited number of time point measurements not sufficient to finely asses IOP changes. These limitations may have biased previous descriptions of physiological IOP rhythm. Recently, extraocular and intraocular devices integrating a pressure sensor for continuous IOP monitoring have been developed and are available for use in humans. The objective of this article is to present the contributions of these new 24-h monitoring devices for the study of the nyctohemeral rhythms. In healthy subjects and untreated glaucoma subjects, a nyctohemeral rhythm is consistently found and frequently characterized by a mean diurnal IOP lower than the mean nocturnal IOP, with a diurnal bathyphase usually in the middle or at the end of the afternoon and a nocturnal acrophase, usually in the middle or at the end of the night. (C) 2016 Elsevier Ltd. All rights reserved.