Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification
Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification
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DOI：
10.1016/j.neuron.2008.02.028
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发表时间：
2008-05-08
期刊：
影响因子：
16.2
通讯作者：
Zuo, Jian
中科院分区：
文献类型：
--
作者：
Dallos, Peter;Wu, Xudong;Zuo, Jian
耳蜗神经生物学的核心原则是哺乳动物的耳朵依赖于局部的机械放大过程，以获得其高灵敏度和尖锐的频率选择性。虽然普遍认为外毛细胞提供放大，但已经提出了两种机制：静纤毛运动和体细胞运动。后者由马达蛋白普雷斯廷驱动。普雷斯廷基因敲除小鼠的电生理表型表明，体细胞运动是放大器。然而，敲除小鼠的外毛细胞具有显著改变的机械特性，使得该小鼠模型不令人满意。在这里，我们研究的小鼠模型没有改变外毛细胞和器官的Corti力学或机电转导，但减少普雷斯廷功能。这些动物具有类似敲除的行为，表明耳蜗放大需要基于prestin的电运动。
It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophysiological phenotyping of a prestin knockout mouse intimated that somatic motility is the amplifier. However, outer hair cells of knockout mice have significantly altered mechanical properties, making this mouse model unsatisfactory. Here, we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function. These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification.