Synthesis of chiral mesoporous silica and its potential application to asymmetric separation
Synthesis of chiral mesoporous silica and its potential application to asymmetric separation
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DOI：
10.1007/s10450-010-9252-z
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发表时间：
2010-08
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影响因子：
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通讯作者：
T. Yokoi;S. Sato;Y. Ara;D. Lu;Y. Kubota;T. Tatsumi
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作者：
T. Yokoi;S. Sato;Y. Ara;D. Lu;Y. Kubota;T. Tatsumi
手性介孔二氧化硅（CMS）已成功地合成在碱性氨基酸的存在下，使用碱性氨基酸与手性阴离子表面活性剂的组合是有利的CMS的形成在扭曲形态的均匀性方面。我们首先证明，由此获得的手性介孔二氧化硅可用于对映选择性分离外消旋化合物;螺旋棒状CMS被发现能够不对称分离外消旋N-三氟乙酰基丙氨酸乙酯（CF 3CO-Ala-OEt）。左旋富集CMS显示L异构体的不对称优先吸附，反之亦然。
Chiral mesoporous silica (CMS) has been successfully synthesized in the presence of basic amino acids; the use of basic amino acids in combination with the chiral anionic surfactant is advantageous for the formation of CMS in terms of uniformity in the twisted morphology. We first demonstrate that thus obtained chiral mesoporous silicas can be used for the enantioselective separation of racemic compounds; the helical rod-shaped CMS is found to be capable of asymmetric separation of racemicN-trifluoroacetylalanine ethyl ester (CF3CO-Ala-OEt). The left handedness-rich CMS shows asymmetric preferential adsorption of the L isomer and vice versa.