Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus
Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus
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DOI：
10.1200/jco.2005.00.034
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发表时间：
2005-04-01
影响因子：
45.3
通讯作者：
Wilke, H
中科院分区：
文献类型：
--
作者：
Stahl, M;Stuschke, M;Wilke, H
目的：放化疗联合或不联合手术是局部晚期食管癌根治性治疗被广泛接受的替代方案。在化疗和放疗基础上增加手术的价值尚不明确。
患者与方法：局部晚期食管鳞状细胞癌（SCC）患者被随机分配到诱导化疗后接受放化疗（40Gy）再进行手术组（A组），或相同的诱导化疗后接受放化疗（至少65Gy）但不手术组（3组）。主要观察指标是总生存时间。
结果：中位观察时间为6年。对172例符合条件的随机患者（每组86例）的分析显示，两个治疗组之间的总生存率相当（等效性的对数秩检验，P
Purpose Combined chemoradiotherapy with and without surgery are widely accepted alternatives for the curative treatment of patients with locally advanced esophageal cancer. The value of adding surgery to chemotherapy and radiotherapy is unknown.Patients and Methods Patients with locally advanced squamous cell carcinoma (SCC) of the esophagus were randomly allocated to either induction chemotherapy followed by chemoradiotherapy (40 Gy) followed by surgery (arm A), or the same induction chemotherapy followed by chemoradiotherapy (at least 65 Gy) without surgery (arm 3). Primary outcome was overall survival time.Results The median observation time was 6 years. The analysis of 172 eligible, randomized patients (86 patients per arm) showed overall survival to be equivalent between the two treatment groups (log-rank test for equivalence, P