Potential In Vivo UVC Disinfection of Catheter Lumens: Estimation of the Doses Received by the Blood Flow Outside the Catheter Tip Hole
Potential In Vivo UVC Disinfection of Catheter Lumens: Estimation of the Doses Received by the Blood Flow Outside the Catheter Tip Hole
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DOI：
10.1111/j.1751-1097.2011.00887.x
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发表时间：
2011-03-01
影响因子：
3.3
通讯作者：
Vorontsova, Inessa
中科院分区：
文献类型：
--
作者：
Bak, Jimmy;Jorgensen, Thomas M.;Vorontsova, Inessa
我们已经证明，可以将UVC LED光发射到细菌污染的聚合物管/导管中，并对这些管的管腔内空间进行消毒。这可以通过定期对导管进行UVC处理来实现。导管在远端配备有出口孔，用于将药物、血液或营养物施用到血流中。即使UVC光在其传播通过导管管体期间被强烈衰减，发射到导管中的UVC的一部分也将通过出口孔逸出并照射血液。我们证明，通过计算，非常小的有效剂量暴露于血液（约10-4 J m-2）。与其他治疗应用报告的UVC剂量相比，该剂量水平非常低。血液成分在出口孔前面的照射体积中的非常短的停留时间是导管应用中UVC暴露于血液如此低的主要原因。血液通过导管头端接收的剂量非常低，表明可能的副作用可以忽略不计，并使紫外线消毒技术在临床环境中可行。
We have demonstrated that it is possible to launch UVC LED light into bacterial contaminated polymer tubes/catheters and disinfect the intraluminal space of these tubes. This can be achieved by UVC treatment of the catheters on a regular basis. Catheters are in the distal end equipped with an exit hole for administration of drugs, bloods or nutrients into the bloodstream. Even if the UVC light is strongly attenuated during its propagation through the catheter tube a fraction of the UVC launched into the catheter will escape through the exit hole and irradiate the blood. We demonstrate by calculations that very small effective doses are exposed to the blood (ca 10-4 J m-2). This dosage level is very low compared with UVC doses reported from other therapeutic applications. The very short residence time of the blood constituents in the irradiated volume in front of the exit hole is the main reason why the UVC exposure to the blood in the catheter application is so low. The very low dose received by the blood through the catheter tip indicated that possible side effects are negligible and makes the UV disinfection technique feasible in a clinical setting.